Sodium Methoxide
Synonym(s):Sodium methoxide, Sodium methanolate;Sodium methylate
- CAS NO.:124-41-4
- Empirical Formula: CH3NaO
- Molecular Weight: 54.02
- MDL number: MFCD00012179
- EINECS: 204-699-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-07 14:24:42
What is Sodium Methoxide?
The Uses of Sodium Methoxide
Sodium methoxide is mainly used as a condensation agent, a strong alkaline catalyst and a methoxylating agent for the production of vitamin B1 and A, sulfadiazine and other drugs, and in small quantities for the production of pesticides. It is also used as a catalyst for treatment ofedible fats and oils, as an intermediate inmany synthetic reactions, to prepare sodiumcellulosate; and as a reagent in chemicalanalysis.
The Uses of Sodium Methoxide
To a solution of the alcohol (A) (86 mg, 482 umol) in anhydrous THF (5 mL) at RT was added NaH (60% dispersion on mineral oil, 21 mg, 526 umol), and the mixture was stirred at RT for 15 min. The aryl chloride (B) (150 mg, 439 umol) was added and the reaction mixture was stirred at RT for 45 min, then 80 C for 2 h. H2O and sat aq NaHCO3 were added and the mixture was extracted with EtOAc, washed with brine, dried (Na2SO4), and concentrated. The resulting material was purified by silica gel column chromatography (0-25% EtOAc/cyclohexane) to provide the product. [137 mg]
Properties of Sodium Methoxide
Melting point: | -98 °C |
Boiling point: | 65 °C |
Density | 0.97 g/mL at 20 °C |
Flash point: | 11 °C |
storage temp. | Store at +5°C to +30°C. |
solubility | Miscible with ethanol, methanol, fats and esters.Immiscible with hydrocarbons and organic solvents. |
form | Powder |
appearance | White solid |
color | , clarity of solution to pass |
Water Solubility | reacts |
Sensitive | Moisture Sensitive |
Safety information for Sodium Methoxide
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H228:Flammable solids H251:Self-heating substances and mixtures H290:Corrosive to Metals H302:Acute toxicity,oral H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P235:Keep cool. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Sodium Methoxide
InChIKey | WQDUMFSSJAZKTM-UHFFFAOYSA-N |
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