4-MALEIMIDOBUTYRIC ACID
Synonym(s):γ-Maleimidobutyric acid;4-Maleimidobutanoic acid;N-(3-Carboxypropyl)maleimide;N-Maleoyl-4-aminobutyric acid;N-Maleoyl-GABA
- CAS NO.：57078-98-5
- Empirical Formula: C8H9NO4
- Molecular Weight: 183.16
- MDL number: MFCD00043139
- EINECS: 611-461-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:56
What is 4-MALEIMIDOBUTYRIC ACID?
Description
4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)butanoic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical properties
White Solid
The Uses of 4-MALEIMIDOBUTYRIC ACID
4-Maleimidobutyric Acid is a short crosslinking reagent.
The Uses of 4-MALEIMIDOBUTYRIC ACID
- A short crosslinking reagent
- Modification reagent for thiol groups in proteins
- Maleimide Derivatives
- MTS & Sulfhydryl Active Reagents
What are the applications of Application
4-Maleimidobutyric Acid is A bifunctional crosslinking agent
Properties of 4-MALEIMIDOBUTYRIC ACID
| Melting point: | 95-98 °C |
| Boiling point: | 400.1±28.0 °C(Predicted) |
| Density | 1.395±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly) |
| form | Solid |
| pka | 4.59±0.10(Predicted) |
| color | White to Pale Yellow |
| BRN | 1455876 |
| CAS DataBase Reference | 57078-98-5(CAS DataBase Reference) |
Safety information for 4-MALEIMIDOBUTYRIC ACID
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-MALEIMIDOBUTYRIC ACID
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