GMBS
Synonym(s):N-(γ-Maleimidobutyryloxy)succinimide;N-Succinimidyl 4-maleimidobutyrate;4-Maleimidobutyric acid N-succinimidyl ester;GMBS;N-γ-Maleimidobutyryloxysuccinimide
- CAS NO.：80307-12-6
- Empirical Formula: C12H12N2O6
- Molecular Weight: 280.23
- MDL number: MFCD00036817
- EINECS: 625-693-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
What is GMBS?
Chemical properties
White Solid
The Uses of GMBS
A short, sulfhydryl and amino reactive heterobifunctional crosslinking reagent. Introduces maleimide groups into IgM
The Uses of GMBS
A heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. Useful in enzyme immunoassays
What are the applications of Application
4-Maleimidobutyric Acid N-Succinimidyl Ester is An amine- and sulfhydryl-reactive crosslinker
Properties of GMBS
| Melting point: | 123-129 °C |
| Boiling point: | 461.3±47.0 °C(Predicted) |
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | chloroform: 100 mg/mL |
| pka | -2.27±0.20(Predicted) |
| form | powder |
| color | White to Pale Yellow |
| BRN | 6427689 |
| Stability: | Hygroscopic, Moisture Sensitive |
| InChI | InChI=1S/C12H12N2O6/c15-8-3-4-9(16)13(8)7-1-2-12(19)20-14-10(17)5-6-11(14)18/h3-4H,1-2,5-7H2 |
Safety information for GMBS
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for GMBS
| InChIKey | PVGATNRYUYNBHO-UHFFFAOYSA-N |
| SMILES | N1(CCCC(ON2C(=O)CCC2=O)=O)C(=O)C=CC1=O |
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