3-Maleimidobenzoic acid N-hydroxysuccinimide ester

Synonym(s):MBS

CAS NO.：58626-38-3
Empirical Formula: C15H10N2O6
Molecular Weight: 314.25
MDL number: MFCD00005514
EINECS: 261-368-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-16 07:06:08

3-Maleimidobenzoic acid N-hydroxysuccinimide ester Structural

What is 3-Maleimidobenzoic acid N-hydroxysuccinimide ester?

Description

MBS is a heterobifunction crosslinker that contains a maleimide group which is reactive towards sulfhydryls and an NHS ester, useful for targeting amine groups.

Chemical properties

Crystalline

The Uses of 3-Maleimidobenzoic acid N-hydroxysuccinimide ester

3-Maleimidobenzoic acid N-hydroxysuccinimide ester is a heterobifunctional coupling reagent useful for forming enzyme immunoconjugates. The reactive groups are the NHS ester and maeimide.

The Uses of 3-Maleimidobenzoic acid N-hydroxysuccinimide ester

N-Succinimidyl 3-maleimidobenzoate is useful for forming enzyme immunoconjugates. It has a 9.9 Angstrom spacer arm. Heterobifunctional crosslinking reagent reactive toward primary amine and sulfhydryl. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates

What are the applications of Application

3-N-Maleimidobenzoic Acid N-Succinimidyl Ester is a heterobifunctional amine- and sulfhydryl-reactive crosslinker, 9.9 Angstrom spacer arm

Biochem/physiol Actions

3-Maleimidobenzoic acid N-hydroxysuccinimide is used as a fixative for the preservation of pollen tube F-actin distribution. It imposes less damage when used on pollen tubes.

Properties of 3-Maleimidobenzoic acid N-hydroxysuccinimide ester

Melting point:	175-177 °C(lit.)
Boiling point:	524.5±52.0 °C(Predicted)
Density	1.59±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	ethyl acetate or DMF: ≤20 mg/mL may require addition of solvent to coupling buffer to at least 5% to maintain solubility
pka	-2.63±0.20(Predicted)
form	crystalline
color	White to Almost white
Sensitive	Moisture & Light Sensitive
BRN	1505254
CAS DataBase Reference	58626-38-3(CAS DataBase Reference)

Safety information for 3-Maleimidobenzoic acid N-hydroxysuccinimide ester

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.