Triethyl 2-phosphonobutyrate

Synonym(s):α-Diethylphosphonobutanoic acid ethyl ester;Ethyl 2-(diethoxyphosphoryl)butanoate;NSC 22423

CAS NO.：17145-91-4
Empirical Formula: C10H21O5P
Molecular Weight: 252.24
MDL number: MFCD00041347
EINECS: 627-866-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:53:48

What is Triethyl 2-phosphonobutyrate?

Chemical properties

clear colorless liquid

The Uses of Triethyl 2-phosphonobutyrate

Reactant used for preparation of furospinosulin-1 and analogs as hypoxia-selective antitumor agents, Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer?s drugs, phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents, PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists, notch-sparing γ-secretase inhibitors derived from PPAR agonist library and plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis.

The Uses of Triethyl 2-phosphonobutyrate

Reactant for preparation of:

Furospinosulin-1 and analogs as hypoxia-selective antitumor agents
Aminoquinolines as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and potential anti-Alzheimer′s drugs
Phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists as nonalcoholic steatohepatitis (NASH)-preventive agents
PPAR agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related LXR antagonists
Notch-sparing γ-secretase inhibitors derived from PPAR agonist library
Plakotenin via Diels-Alder reaction, as a potential anticancer agent, naturally found in Okinawan sponge of the genus Plakortis
Quinone/naphthoquinone-substituted propenoic acids as inhibitors of cell growth and redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor 1 (Ape1/Ref-1)
α-alkenyl cyclic ethers by asymmetric dehydrative cyclization of ω-hydroxy allyl alcohols catalyzed by Ru complexes of axially chiral naphthylpyridinecarboxylates
Branched phosphonoethoxyethyl purines as new acyclic nucleoside phosphonates which inhibit Plasmodium falciparum (malarial parasite) hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT)
Phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists as candidate drugs for treatment of altered metabolic homeostasis

Properties of Triethyl 2-phosphonobutyrate

Boiling point:	152-154 °C14 mm Hg(lit.)
Density	1.064 g/mL at 25 °C(lit.)
refractive index	n20/D 1.432(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
form	Liquid
color	Clear colorless
Specific Gravity	1.064
Water Solubility	Not miscible or difficult to mix with water.
BRN	1789280

Safety information for Triethyl 2-phosphonobutyrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.