Triethyl 2-phosphonopropionate
Synonym(s):2-(Diethoxyphosphoryl)propionic acid ethyl ester
- CAS NO.：3699-66-9
- Empirical Formula: C9H19O5P
- Molecular Weight: 238.22
- MDL number: MFCD00009159
- EINECS: 223-033-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-10-27 18:05:18
What is Triethyl 2-phosphonopropionate?
Chemical properties
CLEAR COLOURLESS LIQUID
The Uses of Triethyl 2-phosphonopropionate
Triethyl 2-Phosphonopropionate is used in studies involving insecticides and their efficacy on various bacterium. Also act as inhibitors of Epstein-Bar virus transmission and infections.
The Uses of Triethyl 2-phosphonopropionate
Triethyl 2-phosphonopropionate is used as a reactant in intramolecular conjugate addition for the synthesis of floresolide B, enantioselective synthesis of spiroindane di-methyl acetic acid and in stereo selective intramolecular Diels-Alder reactions. It plays an important role in Horner-Wadsworth-Emmons reactions and chemoenzymatic one-pot synthesis of gamma-butyrolactones. It is also used in the preparation of 3-[2]furyl-2-methyl-acrylic acid ethyl ester by reacting with furfural.
Purification Methods
Purify it by fractional distillation with high reflux ratio, preferably using a spinning band column. [Kosolapoff & Powell J Am Chem Soc 72 4198 1950, Kresze et al. Justus Liebigs Ann Chem 756 112 1972, Beilstein 4 IV 3617.]
Properties of Triethyl 2-phosphonopropionate
| Melting point: | 161-164° |
| Boiling point: | 143-144 °C12 mm Hg(lit.) |
| Density | 1.111 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 192 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Miscible with chloroform and methanol. |
| form | Liquid |
| color | Clear colorless |
| Specific Gravity | 1.111 |
| BRN | 1786994 |
| CAS DataBase Reference | 3699-66-9(CAS DataBase Reference) |
Safety information for Triethyl 2-phosphonopropionate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H227:Flammable liquids |
| Precautionary Statement Codes |
P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for Triethyl 2-phosphonopropionate
| InChIKey | BVSRWCMAJISCTD-UHFFFAOYSA-N |
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