Triethylamine trihydrofluoride

Synonym(s):Hydrogen fluoride triethylamine;TREAT-HF;Triethylamine trishydrofluoride

CAS NO.：73602-61-6
Empirical Formula: C6H18F3N
Molecular Weight: 161.21
MDL number: MFCD00043294
EINECS: 277-550-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-20 17:40:16

Triethylamine trihydrofluoride Structural

What is Triethylamine trihydrofluoride?

Chemical properties

clear yellow liquid

The Uses of Triethylamine trihydrofluoride

Triethylamine trihydrofluoride acts as a mild and selective fluorinating agent used in the synthesis of acid fluorides and alkyl fluorides. It is also used in the synthesis of vicinal difluorides from epoxides, 3-fluoroazetidine. It is utilized as a selective reagent for the cleavage of O-silyl groups in carbohydrates, nucleotides and cyanohydrins. It is actively involved in the electrochemical fluorodeiodination of alkyl iodides and fluorodesilylation in beta-lactams.

The Uses of Triethylamine trihydrofluoride

Mild and selective reagent that has been used in the fluorination of a wide variety of compounds. For a review, see Aldrichimica Acta.

General Description

Triethylamine trihydrofluoride (TREAT-HF) is a mild and selective reagent for the fluorination of a wide variety of compounds.

Properties of Triethylamine trihydrofluoride

Melting point:	-29--27°C
Boiling point:	70 °C15 mm Hg(lit.)
Density	0.989 g/mL at 25 °C(lit.)
refractive index	n20/D 1.3915(lit.)
Flash point:	190 °F
storage temp.	Store below +30°C.
solubility	soluble in Chloroform, Hexane
form	Liquid
Specific Gravity	0.989
color	Clear yellow to brown
PH	3 (H2O, 20℃)(saturated aqueous solution)
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	5522945
Exposure limits	ACGIH: TWA 2.5 mg/m3 NIOSH: IDLH 250 mg/m3
CAS DataBase Reference	73602-61-6(CAS DataBase Reference)
EPA Substance Registry System	Ethanamine, N,N-diethyl-, trihydrofluoride (73602-61-6)

Safety information for Triethylamine trihydrofluoride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.