Naphazoline hydrochloride

Chemical properties

White or almost white, crystalline powder.

Originator

Albalon,Allergan,Australia

The Uses of Naphazoline hydrochloride

Naphazoline Hydrochloride is a useful synthetic intermediate used in eye drops. A vasoconstrictor.

The Uses of Naphazoline hydrochloride

antihistamine

What are the applications of Application

Naphazoline Hydrochloride is a producer ionotropic effects via α-adrenoceptor stimulation

Definition

ChEBI: Naphazoline is an organic molecular entity.

Manufacturing Process

2.7 parts of naphtyl-(1)-acetiminoethylether (produced from naphthyl-1- acetonitrile) were dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the mixture was heated to gentle boiling while passing it through nitrogen and simultaneously stirring until ammonia escaped no longer. The alcohol was is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring was continued for some time whereby the imidazoline base was dissolved in benzene. The benzene residue, is recrystallized several times from toluene. The 2-[naphthyl-1-methyl]-imidazoline represented the coloriless crystalls of melting point 252°-253°C. Its hydrochloride is easily soluble in water.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Vasoconstrictor, Nasal decongestant

Description

Naphazoline hydrochloride is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations.