N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Synonym(s):N-Methyl-N-(trimethylsilyl)trifluoroacetamide;N-Trimethylsilyl-N-methyl trifluoroacetamide;2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide;MSTFA;N-Methyl-N-trimethylsilyl-trifluoroacetamide
- CAS NO.：24589-78-4
- Empirical Formula: C6H12F3NOSi
- Molecular Weight: 199.25
- MDL number: MFCD00000411
- EINECS: 246-331-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 17:20:11
What is N-Methyl-N-(trimethylsilyl)trifluoroacetamide?
Chemical properties
Clear colorless to light yellow liquid
The Uses of N-Methyl-N-(trimethylsilyl)trifluoroacetamide
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.
The Uses of N-Methyl-N-(trimethylsilyl)trifluoroacetamide
A new metabolite of Famprofazone in humans.
What are the applications of Application
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is silylating agent that forms volatile derivatives for GC-MS analysis
Definition
ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.
General Description
N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.
Purification Methods
Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]
Properties of N-Methyl-N-(trimethylsilyl)trifluoroacetamide
| Melting point: | 98-100°C |
| Boiling point: | 130132°C |
| Density | 1.075 g/mL at 25 °C(lit.) |
| vapor density | >1 (vs air) |
| vapor pressure | 8.8 mm Hg ( 27 °C) |
| refractive index | n |
| Flash point: | 77 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | -1.34±0.70(Predicted) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.076 |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1941550 |
| CAS DataBase Reference | 24589-78-4(CAS DataBase Reference) |
| EPA Substance Registry System | Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4) |
Safety information for N-Methyl-N-(trimethylsilyl)trifluoroacetamide
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Methyl-N-(trimethylsilyl)trifluoroacetamide
| InChIKey | MSPCIZMDDUQPGJ-UHFFFAOYSA-N |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide manufacturer
New Products
1,3-Dichloroacetone Ethylene Ketal 1-N-Boc-3-(aminoethyl)azetidine 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROPYRAN AMino-(3-Methylphenyl)-acetic acid 3-AMINO-3-(2-CHLORO-PHENYL)-PROPIONIC ACID 4-Fluorophenylglycine 4, 4'-Ditolylamine (or) 4,4-Dimethyl Diphenylamine 2-Bromo-5-Chloropyridine 2-Picolinic acid N-oxide 4-Butyl Resorcinol 2-(2,4-Diaminophenoxy)ethanol Dihydrochloride 5-Bromo-2-Hydroxy-3-Nitro Pyridine 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile Tetracaine Hydrochloride Ep Grade 2,2,2-Trichloroethyl chloroformate 5-Bromo-4-chloro-3-indolyl-β-D-galactopyranoside 4-Pentyn-1-ol 2-Bromo-6-fluoroaniline 5-fluoro-1,3-benzodioxole 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 2-(Chloromethyl) quinazolin-4(3H)-one 2-Amino-4-phenyl-thiazole 4-Chloro-2-methyl quinolineRelated products of tetrahydrofuran
You may like
-
MSTFA+TMCS (99:1) CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-trimethylsilyltrifluoroacetamide [Trimethylsilylating Agent] CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-Trimethylsilyl Trifluoroacetamide (MSTFA) extrapure CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-(trimethylsilyl)trifluoroacetamide 97.00% CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97% CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-trimethylsilyltrifluoroacetamide activated I CASView Details
-
N-Methyl-N-trimethylsilyltrifluoroacetamide activated II CASView Details
-
N-Methyl-N-trimethylsilyl-trifluoroacetamide CAS 24589-78-4View Details
24589-78-4