N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Synonym(s):N-Methyl-N-(trimethylsilyl)trifluoroacetamide;N-Trimethylsilyl-N-methyl trifluoroacetamide;2,2,2-Trifluoro-N-methyl-N-(trimethylsilyl)acetamide;MSTFA;N-Methyl-N-trimethylsilyl-trifluoroacetamide
- CAS NO.：24589-78-4
- Empirical Formula: C6H12F3NOSi
- Molecular Weight: 199.25
- MDL number: MFCD00000411
- EINECS: 246-331-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-25 17:15:13
What is N-Methyl-N-(trimethylsilyl)trifluoroacetamide?
Chemical properties
Clear colorless to light yellow liquid
The Uses of N-Methyl-N-(trimethylsilyl)trifluoroacetamide
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is used as a silylating reagent that forms volatile derivatives for GC-MS analysis. It acts as a pharmaceutical intermediate and metabolite of Famprofazone in humans. It is also used in the detection of steroid hormones 17-alfa-ethynylestradiol and estrone.
The Uses of N-Methyl-N-(trimethylsilyl)trifluoroacetamide
A new metabolite of Famprofazone in humans.
What are the applications of Application
N-Methyl-N-(trimethylsilyl)trifluoroacetamide is silylating agent that forms volatile derivatives for GC-MS analysis
Definition
ChEBI: An N-silyl compound that is N-methyltrifluoroacetamide in which the amide nitrogen is replaced by a trimethylsilyl group. N-methyl-N-(trimethylsilyl)trifluoroacetamide is a derivat sation agent used in gas chromatography/mass spectrometry applications.
General Description
N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.
Purification Methods
Fractionate the amide through a 40mm Vigreux column (p 11). Usually it contains ca 1% of methyl trifluoroacetamide and 1% of other impurities which can be removed by gas chromatography or fractionating using a spinning band column. [Donike J Chromatogr 42 103 1969, Donike J Chromatogr 103 91 1975, Beilstein 4 IV 4011.]
Properties of N-Methyl-N-(trimethylsilyl)trifluoroacetamide
| Melting point: | 98-100°C |
| Boiling point: | 130132°C |
| Density | 1.075 g/mL at 25 °C(lit.) |
| vapor density | >1 (vs air) |
| vapor pressure | 8.8 mm Hg ( 27 °C) |
| refractive index | n |
| Flash point: | 77 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | -1.34±0.70(Predicted) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Specific Gravity | 1.076 |
| Water Solubility | reacts |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 7: reacts slowly with moisture/water |
| BRN | 1941550 |
| CAS DataBase Reference | 24589-78-4(CAS DataBase Reference) |
| EPA Substance Registry System | Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)- (24589-78-4) |
Safety information for N-Methyl-N-(trimethylsilyl)trifluoroacetamide
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Methyl-N-(trimethylsilyl)trifluoroacetamide
| InChIKey | MSPCIZMDDUQPGJ-UHFFFAOYSA-N |
N-Methyl-N-(trimethylsilyl)trifluoroacetamide manufacturer
JSK Chemicals
New Products
Boc-N-Me-Val-OH tert-butyl 9-methoxy-3-azaspiro[5.5]undecane-3-carboxylate Indole Methyl Resin Gabapentin EP Impurity B Ethyl N-(2- cyanoacetyl)carbamate Magnessium Ascorbate 1-Chloro-4-Methyl-2-Nitrobenzene 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,4-dihydroxybenzaldehyde 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile Benzethonium Chloride Trenbolone Enanthate Prednisolone acetate Cisplatin Chlorodehydromethyl testosterone Ketoconazole 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 3-Hydroxy-4-nitrobromobenzene 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoateRelated products of tetrahydrofuran
You may like
-
MSTFA+TMCS (99:1) CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-trimethylsilyltrifluoroacetamide [Trimethylsilylating Agent] CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-Trimethylsilyl Trifluoroacetamide (MSTFA) extrapure CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-(trimethylsilyl)trifluoroacetamide 97.00% CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-(trimethylsilyl)trifluoroacetamide, 97% CAS 24589-78-4View Details
24589-78-4 -
N-Methyl-N-trimethylsilyltrifluoroacetamide activated I CASView Details
-
N-Methyl-N-trimethylsilyltrifluoroacetamide activated II CASView Details
-
N-Methyl-N-trimethylsilyl-trifluoroacetamide CAS 24589-78-4View Details
24589-78-4