Trifluoroacetamide

Synonym(s):2,2,2-Trifluoroacetamide

CAS NO.：354-38-1
Empirical Formula: C2H2F3NO
Molecular Weight: 113.04
MDL number: MFCD00008008
EINECS: 206-559-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 17:34:32

What is Trifluoroacetamide?

Chemical properties

white to pale yellow or beige crystalline powder

The Uses of Trifluoroacetamide

2,2,2-Trifluoroacetamide used in a convenient alternative to the Gabriel synthesis of primary amines from halides by N-alkylation followed by cleavage of the readily-hydrolyzed trifluoroacetyl group and for improved N-alkylation under phase-transfer conditions allowing successive alkylation with different alkyl groups.

What are the applications of Application

Trifluoroacetamide was used as probe for determination of membrane potential and extra/intracellular volume of erythrocytes by fluorine-19 NMR studies.

Preparation

One-pot synthetic approach to produce trifluoroacetamide has been developed using an electrochemical method with the B12 complex as a catalyst under mild conditions, in open air at room temperature. Thirty examples of trifluoroacetamide were synthesized from 1,1,1-trichloro-2,2,2-trifluoroethane (CFC-113a) in moderate to good yields. This user-friendly strategy is compatible with a broad range of trifluoroacetamide syntheses.
10.1142/S1088424621500292

General Description

Trifluoroacetamide is a good quencher of tryptophan fluorescence.

Properties of Trifluoroacetamide

Melting point:	65-70 °C (lit.)
Boiling point:	162.5 °C (lit.)
Density	1.4176 (estimate)
Flash point:	162-164°C
storage temp.	Store below +30°C.
solubility	460 g/L (20°C)
form	Crystalline Powder or Crystals
pka	12.33±0.50(Predicted)
color	White to pale yellow or beige
PH	3.6 (460g/l, H2O, 23℃)
Water Solubility	460 g/L (20 ºC)
BRN	1753625
CAS DataBase Reference	354-38-1(CAS DataBase Reference)
NIST Chemistry Reference	Acetamide, 2,2,2-trifluoro-(354-38-1)
EPA Substance Registry System	Acetamide, 2,2,2-trifluoro- (354-38-1)

Safety information for Trifluoroacetamide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.