Trifluoroacetophenone

Synonym(s):α,α,α-Trifluoroacetophenone;Phenyl trifluoromethyl ketone

CAS NO.：434-45-7
Empirical Formula: C8H5F3O
Molecular Weight: 174.12
MDL number: MFCD00000420
EINECS: 207-103-1
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:42

What is Trifluoroacetophenone?

Chemical properties

CLEAR COLORLESS TO YELLOW LIQUID

The Uses of Trifluoroacetophenone

2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptos is in cerebellar granule neurons.

The Uses of Trifluoroacetophenone

General Description

2,2,2-Trifluoroacetophenone is the starting material for the synthesis of f 3-trifluoromethyl-3-phenyldiazirine. It undergoes asymmetric reduction with optically active Grignard reagent to form 2,2,2-trifluoro-1-phenylethanol. It undergoes condensation with biphenyl, terphenyl, a mixture of biphenyl with terphenyl, phenyl ether and diphenoxybenzophenone to form new aromatic 3F polymers.

Properties of Trifluoroacetophenone

Melting point:	-40 °C
Boiling point:	165-166 °C (lit.) 46-48 °C/14 mmHg (lit.)
Density	1.24 g/mL at 25 °C (lit.)
refractive index	n20/D 1.458(lit.)
Flash point:	107 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Ethyl Acetate
form	Liquid
color	Clear colorless to yellow
Specific Gravity	1.240
Water Solubility	PRACTICALLY INSOLUBLE
BRN	1866286
CAS DataBase Reference	434-45-7(CAS DataBase Reference)
NIST Chemistry Reference	Ethanone, 2,2,2-trifluoro-1-phenyl-(434-45-7)
EPA Substance Registry System	Ethanone, 2,2,2-trifluoro-1-phenyl- (434-45-7)

Safety information for Trifluoroacetophenone

Signal word	Warning
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.