Trifluoroacetophenone
Synonym(s):α,α,α-Trifluoroacetophenone;Phenyl trifluoromethyl ketone
- CAS NO.：434-45-7
- Empirical Formula: C8H5F3O
- Molecular Weight: 174.12
- MDL number: MFCD00000420
- EINECS: 207-103-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 04:55:41
What is Trifluoroacetophenone?
Chemical properties
CLEAR COLORLESS TO YELLOW LIQUID
The Uses of Trifluoroacetophenone
2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptos is in cerebellar granule neurons.
The Uses of Trifluoroacetophenone
2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptosis in cerebellar granule neurons.
General Description
2,2,2-Trifluoroacetophenone is the starting material for the synthesis of f 3-trifluoromethyl-3-phenyldiazirine. It undergoes asymmetric reduction with optically active Grignard reagent to form 2,2,2-trifluoro-1-phenylethanol. It undergoes condensation with biphenyl, terphenyl, a mixture of biphenyl with terphenyl, phenyl ether and diphenoxybenzophenone to form new aromatic 3F polymers.
Properties of Trifluoroacetophenone
| Melting point: | -40 °C |
| Boiling point: | 165-166 °C (lit.)
46-48 °C/14 mmHg (lit.) |
| Density | 1.24 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 107 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Liquid |
| color | Clear colorless to yellow |
| Specific Gravity | 1.240 |
| Water Solubility | PRACTICALLY INSOLUBLE |
| BRN | 1866286 |
| CAS DataBase Reference | 434-45-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanone, 2,2,2-trifluoro-1-phenyl-(434-45-7) |
| EPA Substance Registry System | Ethanone, 2,2,2-trifluoro-1-phenyl- (434-45-7) |
Safety information for Trifluoroacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Flame Flammables GHS02  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H226:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Trifluoroacetophenone
| InChIKey | KZJRKRQSDZGHEC-UHFFFAOYSA-N |
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