H-7 DIHYDROCHLORIDE
Synonym(s):1-(5-Isoquinolinesulfonyl)-2-methylpiperazine, 2HCl;1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride;H-7 dihydrochloride;H-7, Dihydrochloride - CAS 108930-17-2 - Calbiochem;Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
- CAS NO.：108930-17-2
- Empirical Formula: C14H19Cl2N3O2S
- Molecular Weight: 364.29
- MDL number: MFCD00036961
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-27 08:46:37
What is H-7 DIHYDROCHLORIDE?
Chemical properties
White Crystalline Solid
The Uses of H-7 DIHYDROCHLORIDE
H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.
The Uses of H-7 DIHYDROCHLORIDE
A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases
What are the applications of Application
H-7, Dihydrochloride is an ATP-competitive Ser/Thr kinase inhibitor
Definition
ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.
General Description
A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (Ki = 97 μM), protein kinase A (Ki = 3.0 μM), protein kinase C (Ki = 6 μM), and protein kinase G (Ki = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.
Biochem/physiol Actions
Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively
Storage
Store at RT
Properties of H-7 DIHYDROCHLORIDE
| Melting point: | 215-225 °C |
| storage temp. | 2-8°C |
| solubility | H2O: 20 mg/mL |
| form | Light yellow lyophilized solid |
| color | White to Off-White |
| BRN | 5840763 |
| CAS DataBase Reference | 108930-17-2(CAS DataBase Reference) |
Safety information for H-7 DIHYDROCHLORIDE
Computed Descriptors for H-7 DIHYDROCHLORIDE
New Products
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