2-Methylpiperazine
- CAS NO.：109-07-9
- Empirical Formula: C5H12N2
- Molecular Weight: 100.16
- MDL number: MFCD00005954
- EINECS: 203-644-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-15 08:02:09
What is 2-Methylpiperazine?
Chemical properties
white to yellow crystalline powder and chunks
The Uses of 2-Methylpiperazine
2-Methylpiperazine is used as a reagent in the design, synthesis and biological evaluation of diaminoquinazolines as b-catenine/Tcell transcription factor 4 (Tcf4) pathway inhibitor.
Purification Methods
Purify it by zone melting and by distillation. It is hygroscopic. The picrate has m 275-276o. [Beilstein 23 II 16, 23 III/IV 393, 23/3 V 267.]
Properties of 2-Methylpiperazine
| Melting point: | 61-63 °C (lit.) |
| Boiling point: | 155 °C/763 mmHg (lit.) |
| Density | 0.817 g/cm |
| refractive index | 1.4378 (estimate) |
| Flash point: | 149 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | 435g/l |
| pka | pK1:5.62(+2);pK2:9.60(+1) (25°C) |
| form | Crystalline Powder, Crystals and/or Chunks |
| color | White to yellow |
| PH | 11-12 (50g/l, H2O) |
| Water Solubility | 78 g/100 mL (25 ºC) |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 383566 |
| CAS DataBase Reference | 109-07-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Piperazine, 2-methyl-(109-07-9) |
| EPA Substance Registry System | Piperazine, 2-methyl- (109-07-9) |
Safety information for 2-Methylpiperazine
| Signal word | Danger |
| Pictogram(s) |
 Flame Flammables GHS02  Corrosion Corrosives GHS05 |
| GHS Hazard Statements |
H228:Flammable solids H314:Skin corrosion/irritation |
| Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P240:Ground/bond container and receiving equipment. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methylpiperazine
| InChIKey | JOMNTHCQHJPVAZ-UHFFFAOYSA-N |
2-Methylpiperazine manufacturer
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