DPQ
Synonym(s):3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone;3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline;PARP Inhibitor III, DPQ - CAS 129075-73-6 - Calbiochem
- CAS NO.：129075-73-6
- Empirical Formula: C18H26N2O2
- Molecular Weight: 302.41
- MDL number: MFCD02258932
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:20:45
What is DPQ?
Description
The poly(ADP-
The Uses of DPQ
DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.
The Uses of DPQ
3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons e to reactive oxygen and nitrogen species.
The Uses of DPQ
Reagent for inhibition of PARP.
What are the applications of Application
DPQ is a highly potent, selective PARP inhibitor
Biochem/physiol Actions
3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.
Storage
+4°C
Properties of DPQ
| Melting point: | 107-109° |
| Boiling point: | 528.8±50.0 °C(Predicted) |
| Density | 1.096±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: Soluble |
| form | solid |
| pka | 14.54±0.20(Predicted) |
| color | White to off-white |
Safety information for DPQ
Computed Descriptors for DPQ
New Products
1-Aminocyclopentane carbonitrile 3-Amino-3-(4-fluorophenyl)propanoic acid N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid (R)-1-Benzyl-3-pyrrolidinecarbonitrile Ursodeoxycholic Acid - Impurity G/Ursodeoxycholic Acid Methyl Ester Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 2-Chloro Benzylcyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanide 3-Hydroxypropionitrile 4-Bromo BenzylcyanideRelated products of tetrahydrofuran
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