NU1025
Synonym(s):8-Hydroxy-2-methylquinazolin-4[3H]-one;8-Hydroxy-2-methylquinazoline-4-one;PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem
- CAS NO.：90417-38-2
- Empirical Formula: C9H8N2O2
- Molecular Weight: 176.17
- MDL number: MFCD00942555
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-02-02 18:10:39
What is NU1025?
Description
NU 1025 is an inhibitor of poly(ADP-
Chemical properties
Off-White to Pale Yellow Solid
The Uses of NU1025
A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively
The Uses of NU1025
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]
The Uses of NU1025
A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
What are the applications of Application
NU 1025 is a potent PARP-1 and Topo I inhibitor
Definition
ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Biological Activity
Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.
Properties of NU1025
| Melting point: | 253-258°C |
| Boiling point: | 345.4±44.0 °C(Predicted) |
| Density | 1.42 |
| storage temp. | −20°C |
| solubility | DMSO: 35 mg/mL, soluble |
| form | solid |
| pka | 8.68±0.20(Predicted) |
| color | off-white |
| CAS DataBase Reference | 90417-38-2 |
Safety information for NU1025
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for NU1025
New Products
N,O-Dimethylhydroxylamine hydrochloride DL-beta-(3-Bromophenyl)alanine N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid (R)-1-Benzyl-3-pyrrolidinecarbonitrile Bupropian related compound F Lantanoprost rc B Clidinium Bromide Impurity Noradrenaline EP Impurity D/Noradrenaline Methyl Ether Cetirizine EP Impurity A/Cetirizine CBHP Impurity N-Nitroso hydroxy Cetrizine EP Impurity-A 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile 4-Fluorothiophenol (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 2-Chloro Benzylcyanide 3-chlorobenzyl cyanide 3,4 Diethoxy Benzylcyanide 3,4 Dimethoxy Benzylcyanide 3-Hydroxypropionitrile 4-Bromo BenzylcyanideRelated products of tetrahydrofuran
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