DMT-2′Fluoro-dU Phosphoramidite
Synonym(s):DMT-2′-Fluoro-dU amidite
- CAS NO.：146954-75-8
- Empirical Formula: C39H46FN4O8P
- Molecular Weight: 748.78
- MDL number: MFCD11113919
- EINECS: 2017-001-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-21 16:59:09
What is DMT-2′Fluoro-dU Phosphoramidite?
The Uses of DMT-2′Fluoro-dU Phosphoramidite
5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.
Definition
DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA
Properties of DMT-2′Fluoro-dU Phosphoramidite
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| form | powder |
| pka | 9.39±0.10(Predicted) |
| color | white to off-white |
Safety information for DMT-2′Fluoro-dU Phosphoramidite
Computed Descriptors for DMT-2′Fluoro-dU Phosphoramidite
| InChIKey | HQHQPAYRJJMYQX-YOKGOYKLNA-N |
| SMILES | N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r| |
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![N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite](https://img.chemicalbook.in/CAS/GIF/104992-55-4.gif)
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