DMT-dG(ib) Phosphoramidite

Synonym(s):DMT-dG(ib) amidite;DMT-dG(ib) Phosphoramidite;Guanosine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxy-N-(2-methyl-1-oxopropyl)-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];N-(2-methyl-1-oxopropyl)-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxyguanosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite]

CAS NO.：93183-15-4
Empirical Formula: C44H54N7O8P
Molecular Weight: 839.92
MDL number: MFCD00055147
EINECS: 685-519-6
SAFETY DATA SHEET (SDS)
Update Date: 2025-06-04 18:22:10

What is DMT-dG(ib) Phosphoramidite?

The Uses of DMT-dG(ib) Phosphoramidite

2’-Deoxy-5’-O-DMT-N2-isobutyrylguanosine 3’-CE Phosphoramidite is used to prepare antisense oligonucleotides containing conformationally constrained methoxyaminomethylene and aminooxymethylene and aminomethylene bridged nucleoside analogs.

Definition

5'-O-DMT-N2-Isobutyryl-2'-Deoxyguanosine-CE Phosphoramidite (DMT-dG(ib) Phosphoramidite) is a nucleoside phosphoramidite that contains an isobutyryl group, and it can be used in the synthesis of oligonucleotides.

Storage

-20°C, stored under nitrogen.
In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Properties of DMT-dG(ib) Phosphoramidite

Density	1.22 at 20℃
vapor pressure	0-0Pa at 20-50℃
storage temp.	Sealed in dry,2-8°C
solubility	soluble, clear
form	powder or granules
pka	9.16±0.20(Predicted)
color	white to off-white

Safety information for DMT-dG(ib) Phosphoramidite

Computed Descriptors for DMT-dG(ib) Phosphoramidite

InChIKey	FDRMKYVTIFSDPR-MMROLVBFSA-N
SMILES	C(OC[C@H]1O[C@@H](N2C=NC3C(=O)NC(NC(=O)C(C)C)=NC2=3)C[C@@H]1OP(OCCC#N)N(C(C)C)C(C)C)(C1=CC=CC=C1)(C1=CC=C(OC)C=C1)C1=CC=C(OC)C=C1 \|&1:3,5,23,r\|