DMT-2'O-TBDMS-rA(bz) Phosphoramidite
Synonym(s):DMT-2’O-TBDMS-rA(bz) Amidite;N-benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-O-[(1,1-dimethylethyl)dimethylsilyl]-adenosine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]
- CAS NO.：104992-55-4
- Empirical Formula: C53H66N7O8PSi
- Molecular Weight: 988.19
- MDL number: MFCD00080297
- EINECS: 2017-001-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 01:55:20
What is DMT-2'O-TBDMS-rA(bz) Phosphoramidite?
The Uses of DMT-2'O-TBDMS-rA(bz) Phosphoramidite
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
The Uses of DMT-2'O-TBDMS-rA(bz) Phosphoramidite
DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Synthesis
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)
Properties of DMT-2'O-TBDMS-rA(bz) Phosphoramidite
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| form | powder |
| pka | 7.87±0.43(Predicted) |
| color | white to off-white |
Safety information for DMT-2'O-TBDMS-rA(bz) Phosphoramidite
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DMT-2'O-TBDMS-rA(bz) Phosphoramidite
| InChIKey | FFXHNCNNHASXCT-RFMFGJHUSA-N |
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