3,4-Dichlorophenol

Synonym(s):3,4-DCP

CAS NO.：95-77-2
Empirical Formula: C6H4Cl2O
Molecular Weight: 163
MDL number: MFCD00002258
EINECS: 202-450-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 3,4-Dichlorophenol?

Chemical properties

light yellow to brown crystals

The Uses of 3,4-Dichlorophenol

3,4-Dichlorophenol (3,4-DCP) is used in the synthesis of (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) agent. It can also be used in the preparation of 2-(3,4-dichlorophenoxy)-N-(2-morpholin-4-ylethyl)acetamide for the treatment of inflammatory pain.

Definition

ChEBI: 3,4-Dichlorophenol is a dichlorophenol.

General Description

Needles (from benzene, petroleum ether) or light brown and yellow crystals. Odor threshold 100 μg/L. Taste threshold 0.3 μg/L in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

3,4-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.

Fire Hazard

Flash point data for 3,4-Dichlorophenol are not available. 3,4-Dichlorophenol is probably combustible.

Purification Methods

Crystallise 3,4-dichlorophenol from pet ether/*benzene mixture and/or distil it. [Beilstein 6 IV 952.]

Properties of 3,4-Dichlorophenol

Melting point:	65-67 °C(lit.)
Boiling point:	145-146 °C(lit.)
Density	1.3446 (rough estimate)
refractive index	1.4430 (estimate)
Flash point:	252-255°C
storage temp.	0-6°C
solubility	9260mg/l (experimental)
form	Powder
pka	pK1:8.630 (25°C)
color	White to brownish
Water Solubility	<0.1 g/100 mL at 20 ºC
BRN	1907693
Stability:	Stable. Combustible. Incompatible with oxidizing agents, acid chlorides, acid anhydrides.
CAS DataBase Reference	95-77-2(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 3,4-dichloro-(95-77-2)
EPA Substance Registry System	3,4-Dichlorophenol (95-77-2)

Safety information for 3,4-Dichlorophenol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.