2,3-Dichlorophenol

Synonym(s):2,3-Dichlorophenol

CAS NO.：576-24-9
Empirical Formula: C6H4Cl2O
Molecular Weight: 163
MDL number: MFCD00002160
EINECS: 209-399-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-09-25 17:15:13

What is 2,3-Dichlorophenol?

Chemical properties

2,3-dichlorophenol appears as light brown crystalline solid. Soluble in ether, chloroform and hot ethanol, insoluble in water and benzene.

The Uses of 2,3-Dichlorophenol

2,3-Dichlorophenol is a chemical reagent used in the synthesis of a small molecule IL-2 inhibitor.

Preparation

2,3-Dichlorophenol is obtained from 1,2,3-trichlorobenzene by sulfonation to salt and high pressure hydrolysis to 3,4-dichloro-2-hydroxybenzenesulfonic acid, then hydrolyzed by sulfuric acid to remove the sulfonic acid group.

General Description

Brown crystals (from ligroin, benzene). Taste threshold concentration 0.00004 mg/L. Odor threshold concentration 0.03 mg/L.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,3-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.

Fire Hazard

Flash point data for 2,3-Dichlorophenol are not available. 2,3-Dichlorophenol is probably combustible.

Purification Methods

Crystallise it from ether. [Beilstein 6 IV 883.]

Properties of 2,3-Dichlorophenol

Melting point:	56 °C
Boiling point:	214 °C
Density	1.40 g/cm3 (25℃)
refractive index	1.4430 (estimate)
Flash point:	115 °C
storage temp.	0-6°C
solubility	3600mg/l (experimental)
form	neat
pka	7.44(at 25℃)
color	White to Light red to Green
Water Solubility	<0.1 g/100 mL at 20 ºC
BRN	2043615
Stability:	Stable. Incompatible with oxidizing agents, acid chlorides, acid anhydrides.
CAS DataBase Reference	576-24-9(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 2,3-dichloro-(576-24-9)
EPA Substance Registry System	2,3-Dichlorophenol (576-24-9)

Safety information for 2,3-Dichlorophenol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.