3,5-Dichlorophenol
- CAS NO.：591-35-5
- Empirical Formula: C6H4Cl2O
- Molecular Weight: 163
- MDL number: MFCD00002259
- EINECS: 209-714-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:13:25
What is 3,5-Dichlorophenol?
Chemical properties
yellow to light brown crystals, crystalline powder
The Uses of 3,5-Dichlorophenol
3,5-Dichlorophenol is used as pharmaceutical intermediate.
Definition
ChEBI: 3,5-dichlorophenol is a dichlorophenol in which the two chloro substituents are located at positions 3 and 5.
What are the applications of Application
3,5-Dichlorophenol is a metabolite of the pesticides polychlorinated phenols and benzene hexachloride. found in chlorinated waste water; Used as a research chemical.
Preparation
Catalytic hydrodechlorination of polychlorophenols in organic or aqueous media with a palladium catalyst was used to obtain 3-chlorophenol and 3,5-dichlorophenol.
Synthesis Reference(s)
Tetrahedron Letters, 25, p. 4565, 1984 DOI: 10.1016/S0040-4039(01)81494-5
General Description
Prisms (from petroleum ether) or pink crystals.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
3,5-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.
Fire Hazard
Flash point data for 3,5-Dichlorophenol are not available. 3,5-Dichlorophenol is probably combustible.
Purification Methods
Crystallise 3,5-dichlorophenol from pet ether/*benzene mixture and/or distil it. [Beilstein 6 IV 957.]
Properties of 3,5-Dichlorophenol
| Melting point: | 65-68 °C (lit.) |
| Boiling point: | 233 °C (lit.) |
| Density | 1.3446 (rough estimate) |
| refractive index | 1.4430 (estimate) |
| Flash point: | 233°C |
| storage temp. | room temp |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | pKa 8.48(H2O t=25 I=0.025) (Uncertain) |
| form | Crystals, Crystalline Powder or Crystalline Mass |
| color | Yellow to light brown |
| Water Solubility | Slightly soluble in water. Very soluble in ethanol, ethyl ether and petroleum ether. |
| BRN | 1906458 |
| CAS DataBase Reference | 591-35-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 3,5-dichloro-(591-35-5) |
| EPA Substance Registry System | 3,5-Dichlorophenol (591-35-5) |
Safety information for 3,5-Dichlorophenol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Skull and Crossbones Acute Toxicity GHS06  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H311:Acute toxicity,dermal H314:Skin corrosion/irritation H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 3,5-Dichlorophenol
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