2,5-Dichlorophenol
Synonym(s):2,5-Dichlo-1-hydroxybenzene;2,5-Dichlorophenol
- CAS NO.：583-78-8
- Empirical Formula: C6H4Cl2O
- Molecular Weight: 163
- MDL number: MFCD00002174
- EINECS: 209-520-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 03:28:50
What is 2,5-Dichlorophenol?
Chemical properties
white to light brown crystals
The Uses of 2,5-Dichlorophenol
2,5-Dichlorophenol is an intermediates in the manufacture of more complex chemical compounds such as fungicides.
The Uses of 2,5-Dichlorophenol
2,5-Dichlorophenol may be used as an analytical reference standard for the determination of the analyte in water, and wood, paper, cardboard, fruits, and fruit juices using simultaneous dispersive liquid-liquid microextraction and derivatization followed by gas chromatography-electron-capture detection (GC-ECD) and gas chromatography-mass spectrometry (GC-MS), respectively.
Definition
ChEBI: A dichlorophenol with the chloro substituents at positions 2 and 5.
Synthesis Reference(s)
Journal of the American Chemical Society, 74, p. 3890, 1952 DOI: 10.1021/ja01135a052
General Description
Prisms (from benzene, petroleum ether) or white crystals. Odor threshold 30 μg/L at 68-72°F; 33 μg/L at 86°F. Taste threshold 0.5 μg/L.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
2,5-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.
Fire Hazard
Flash point data for 2,5-Dichlorophenol are not available. 2,5-Dichlorophenol is probably combustible.
Purification Methods
Crystallise it from ligroin and sublime it in a vacuum or distil it. [Beilstein 6 IV 942.]
Properties of 2,5-Dichlorophenol
| Melting point: | 54-57 °C (lit.) |
| Boiling point: | 211 °C (lit.) |
| Density | 1.3446 (rough estimate) |
| refractive index | 1.4430 (estimate) |
| Flash point: | 100 °C |
| storage temp. | 0-6°C |
| solubility | 2000mg/l (experimental) |
| form | Crystals |
| pka | 7.53±0.10(Predicted) |
| color | White to light brown |
| Water Solubility | 3 g/L (20 ºC) |
| BRN | 1907692 |
| CAS DataBase Reference | 583-78-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Phenol, 2,5-dichloro-(583-78-8) |
| EPA Substance Registry System | 2,5-Dichlorophenol (583-78-8) |
Safety information for 2,5-Dichlorophenol
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,5-Dichlorophenol
2,5-Dichlorophenol manufacturer
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