2,5-Dichlorophenol

Synonym(s):2,5-Dichlo-1-hydroxybenzene;2,5-Dichlorophenol

CAS NO.：583-78-8
Empirical Formula: C6H4Cl2O
Molecular Weight: 163
MDL number: MFCD00002174
EINECS: 209-520-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 03:28:50

What is 2,5-Dichlorophenol?

Chemical properties

white to light brown crystals

The Uses of 2,5-Dichlorophenol

2,5-Dichlorophenol is an intermediates in the manufacture of more complex chemical compounds such as fungicides.

The Uses of 2,5-Dichlorophenol

2,5-Dichlorophenol may be used as an analytical reference standard for the determination of the analyte in water, and wood, paper, cardboard, fruits, and fruit juices using simultaneous dispersive liquid-liquid microextraction and derivatization followed by gas chromatography-electron-capture detection (GC-ECD) and gas chromatography-mass spectrometry (GC-MS), respectively.

Definition

ChEBI: A dichlorophenol with the chloro substituents at positions 2 and 5.

Synthesis Reference(s)

Journal of the American Chemical Society, 74, p. 3890, 1952 DOI: 10.1021/ja01135a052

General Description

Prisms (from benzene, petroleum ether) or white crystals. Odor threshold 30 μg/L at 68-72°F; 33 μg/L at 86°F. Taste threshold 0.5 μg/L.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,5-Dichlorophenol is incompatible with acid chlorides, acid anhydrides and oxidizing agents.

Fire Hazard

Flash point data for 2,5-Dichlorophenol are not available. 2,5-Dichlorophenol is probably combustible.

Purification Methods

Crystallise it from ligroin and sublime it in a vacuum or distil it. [Beilstein 6 IV 942.]

Properties of 2,5-Dichlorophenol

Melting point:	54-57 °C (lit.)
Boiling point:	211 °C (lit.)
Density	1.3446 (rough estimate)
refractive index	1.4430 (estimate)
Flash point:	100 °C
storage temp.	0-6°C
solubility	2000mg/l (experimental)
form	Crystals
pka	7.53±0.10(Predicted)
color	White to light brown
Water Solubility	3 g/L (20 ºC)
BRN	1907692
CAS DataBase Reference	583-78-8(CAS DataBase Reference)
NIST Chemistry Reference	Phenol, 2,5-dichloro-(583-78-8)
EPA Substance Registry System	2,5-Dichlorophenol (583-78-8)

Safety information for 2,5-Dichlorophenol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.