2-Methylindole-3-carboxaldehyde
Synonym(s):3-Formyl-2-methylindole;NSC 11895
- CAS NO.：5416-80-8
- Empirical Formula: C10H9NO
- Molecular Weight: 159.18
- MDL number: MFCD00012077
- EINECS: 226-512-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:23:01
What is 2-Methylindole-3-carboxaldehyde?
Chemical properties
Brown powder
The Uses of 2-Methylindole-3-carboxaldehyde
Reactant for preparation of:• ;Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators1• ;Fluorescent sensors (BODIPY)2• ;Antimicrobial agents against methicillin-resistant Staphylococcus aureus3• ;G protein-coupled receptor CRTh2 antagonists4• ;Inhibitors of PI3 kinase-α5• ;Antitubercular agents6• ;Anti-inflammatory agents7• ;Mycobacterium tuberculosis protein tyrosine phosphatase B8• ;Glucocorticoid receptor ligands9• ;Agents stimulating neurite outgrowth10
The Uses of 2-Methylindole-3-carboxaldehyde
Reactant for preparation of:
- Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Fluorescent sensors (BODIPY)
- Antimicrobial agents against methicillin-resistant Staphylococcus aureus
- G protein-coupled receptor CRTh2 antagonists
- Inhibitors of PI3 kinase-α
- Antitubercular agents
- Anti-inflammatory agents
- Mycobacterium tuberculosis protein tyrosine phosphatase B
- Glucocorticoid receptor ligands
- Agents stimulating neurite outgrowth
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 31, p. 2892, 1983 DOI: 10.1248/cpb.31.2892
General Description
Oxidative activation of 2-methylindole-3-carboxaldehyde via N-heterocyclic carbene organocatalysis generates heterocyclic ortho-quinodimethane as a key intermediate.
Properties of 2-Methylindole-3-carboxaldehyde
| Melting point: | 200-201 °C (lit.) |
| Boiling point: | 344.3±22.0 °C(Predicted) |
| Density | 1.226±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | Powder |
| pka | 16.08±0.30(Predicted) |
| color | Brown |
| CAS DataBase Reference | 5416-80-8(CAS DataBase Reference) |
| EPA Substance Registry System | 1H-Indole-3-carboxaldehyde, 2-methyl- (5416-80-8) |
Safety information for 2-Methylindole-3-carboxaldehyde
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2-Methylindole-3-carboxaldehyde
New Products
Dexamethasone Sodium Phosphate p-Anisaldehyde m-Tolualdehyde 2-Bromobenzaldehyde 4-Fluorobenzaldehyde 1-Propyl-4-piperidone 3-Amino-3-(3-fluorophenyl)propanoic acid Raloxifene EP Impurity D N-Nitroso Nortriptyline Nitroso Irbesartan 2-(p-Tolyl)acetaldehyde Sulfonic acid Impurity 2,2-dibromo-1-cyclopropyl-2-(2-fluorophenyl)ethan-1-one 5-Chloro-2-Methoxy-4-Picoline 2-Amino-6-nitrobenzoic Acid (6-Nitroanthranilic acid) Cis-3,5 Diacetoxy-1-cyclopentene 3-Bromo-2-Methoxy-4-Methylpyridine 2-Amino-5-Chloro-3-Nitro-6-picoline 3-Methoxy-5-methylpyrazin-2-amine Pentachlorobenzonitrile Budesonide Nicotinic acid RAPAMYCIN Alpha CyclodextrinRelated products of tetrahydrofuran
![1-(6-METHOXY-7-METHYL-6H-[1,2,5]OXADIAZOLO[3,4-E]INDOL-8-YL)ETHAN-1-ONE](https://img.chemicalbook.in/CAS/GIF/306935-64-8.gif)
You may like
-
2-Methylindole-3-carboxaldehyde CAS 5416-80-8View Details
5416-80-8 -
2-Methylindole-3-carboxaldehyde CAS 5416-80-8View Details
5416-80-8 -
12029-98-0 >98%View Details
12029-98-0 -
Hydrocortisone 50-23-7 >98%View Details
50-23-7 -
106-43-4 Parachlorotoluene >99%View Details
106-43-4 -
Pyrrolidin >98%View Details
123-75-1 -
cis-p-Menth-2,8-diene-1-ol 7212-40-0 >98%View Details
7212-40-0 -
Para Chloro toluene (PCT) 106-43-4 >99%View Details
106-43-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.