1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

Synonym(s):1,6- bis(Cyclohexyloximinocarbonylamino)hexane;1,6-bis(Cyclohexyloximinocarbonylamino)hexane;RHC-80267 - CAS 83654-05-1 - Calbiochem;U 57908

CAS NO.：83654-05-1
Empirical Formula: C20H34N4O4
Molecular Weight: 394.52
MDL number: MFCD00210844
SAFETY DATA SHEET (SDS)
Update Date: 2025-11-05 08:34:14

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Structural

What is 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE?

Description

RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1

The Uses of 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.

What are the applications of Application

RHC-80267 is a selective inhibitor of DAG lipase and PKC activator

Definition

ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.

General Description

Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.

Biological Activity

Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).

Biochem/physiol Actions

Product does not compete with ATP.

Storage

Store at +4°C

References

1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006 2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247 3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509 4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673 5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717

Properties of 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

Melting point:	118-121℃
Density	1.21±0.1 g/cm3(Predicted)
RTECS	GW1485000
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO: 9 mg/mL
form	solid
pka	13.81±0.46(Predicted)
color	white
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

Safety information for 1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.