Fatostatin A
- CAS NO.：125256-00-0
- Empirical Formula: C18H18N2S
- Molecular Weight: 294.41
- MDL number: MFCD02376000
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-08 17:06:08
What is Fatostatin A?
Description
Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.
The Uses of Fatostatin A
Fatostatin A is Cell permeable inhibitor of SREBP activation.
Definition
ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.
References
1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882 2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329
Properties of Fatostatin A
| Boiling point: | 474.3±55.0 °C(Predicted) |
| Density | 1.125±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | solid |
| pka | 3.46±0.10(Predicted) |
| color | Yellow |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for Fatostatin A
Computed Descriptors for Fatostatin A
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