N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
- CAS NO.：902135-91-5
- Empirical Formula: C16H18Cl3N5O2
- Molecular Weight: 418.7
- MDL number: MFCD14636428
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-04 14:24:59
What is N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl?
Description
AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.
The Uses of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
4-(2,6-DichlorobenzoylaMino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylaMide Monohydrochloride is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.
The Uses of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.
Properties of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
| storage temp. | Store at -20°C |
| solubility | ≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic |
| form | crystalline solid |
| color | White to off-white |
Safety information for N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
Computed Descriptors for N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
New Products
4-Bromo-2-chlorobenzonitrile 1-Chloro-4-Methyl-2-Nitrobenzene 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile Chlorodehydromethyl testosterone Cisplatin Prednisolone acetate Trenbolone Enanthate Benzethonium Chloride Testosterone acetate 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 3-Hydroxy-4-nitrobromobenzene 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Boc-L-Leucinol Calcium Ascorbate Boc-Tyr-OH tert-butyl 2-oxo-1,4,9-triazaspiro[5.5]undecane-9-carboxylate 1-(1-(tert-butoxycarbonyl)piperidin-4-yl)-1H-pyrazole-4-carboxylic acid (1R,5S)-6,6-dimethylbicyclo[3.1.1]heptan-2-oneRelated products of tetrahydrofuran
![4-[(2,6-dichlorobenzoyl)amino]-N-4-piperidinyl1H-pyrazole-3-carboxamide](https://img.chemicalbook.in/CAS2/GIF/844442-38-2.gif)
You may like
-
AT-7519 HCl >95% CAS 902135-91-5View Details
902135-91-5 -
2124221-11-8 (4-(methylamino)phenyl)methanesulfonic acid 98%View Details
2124221-11-8 -
Boc-Arg-OH HCl H2O 114622-81-0 98%View Details
114622-81-0 -
2-(2-chloropyrimidin-4-yl)acetic acid 98%View Details
1211581-39-3 -
15761-38-3 Boc-Ala-OH 98%View Details
15761-38-3 -
42074-68-0 98%View Details
42074-68-0 -
20866-46-0 Boc-His(Boc)-OH 98%View Details
20866-46-0 -
2-(4-(tert-butoxycarbonyl)piperazin-2-yl)acetic acid 98%View Details
183591-72-2