1,2,2,6,6-Pentamethyl-4-piperidinol

Synonym(s):4-Hydroxy-1,2,2,6,6-pentamethylpiperidine;HOPEMP;NSC 364075

CAS NO.：2403-89-6
Empirical Formula: C10H21NO
Molecular Weight: 171.28
MDL number: MFCD00191220
EINECS: 219-292-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-19 22:55:08

1,2,2,6,6-Pentamethyl-4-piperidinol Structural

What is 1,2,2,6,6-Pentamethyl-4-piperidinol?

Chemical properties

LIGHT YELLOW FLAKES

The Uses of 1,2,2,6,6-Pentamethyl-4-piperidinol

1,2,2,6,6-Pentamethyl-4-piperidinol is used in the synthesis of PDGFR kinase inhibitors. Also, it can be applied to the preparation of a new diol-functionalized amine light stabilizer.

The Uses of 1,2,2,6,6-Pentamethyl-4-piperidinol

Reactant for: Synthesis of photostable blue emitting naphthalimides1 Synthesis of blue fluorescent naphthalimide pH chemosensors2 Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen3 Synthesis of spiropyrans and spirooxazines4 Amine photoredox reactions5

The Uses of 1,2,2,6,6-Pentamethyl-4-piperidinol

Reactant for:
Synthesis of photostable blue emitting naphthalimides
Synthesis of blue fluorescent naphthalimide pH chemosensors
Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen
Synthesis of spiropyrans and spirooxazines
Amine photoredox reactions

What are the applications of Application

1,2,2,6,6-Pentamethyl-4-piperidinol is a building block useful for introducing a very hindered amine

Flammability and Explosibility

Non flammable

Properties of 1,2,2,6,6-Pentamethyl-4-piperidinol

Melting point:	72-76 °C
Boiling point:	238 °C
Density	0.967
vapor pressure	0.845Pa at 25℃
refractive index	1.4621 (estimate)
Flash point:	118 °C
storage temp.	Sealed in dry,Room Temperature
form	Flakes
pka	14.93±0.60(Predicted)
color	Light yellow
Water Solubility	4.8 g/100 mL (20 ºc)
BRN	1498
CAS DataBase Reference	2403-89-6(CAS DataBase Reference)
EPA Substance Registry System	4-Piperidinol, 1,2,2,6,6-pentamethyl- (2403-89-6)

Safety information for 1,2,2,6,6-Pentamethyl-4-piperidinol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H314:Skin corrosion/irritation H317:Sensitisation, Skin H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.