1,2,2,6,6-Pentamethyl-4-piperidinol
Synonym(s):4-Hydroxy-1,2,2,6,6-pentamethylpiperidine;HOPEMP;NSC 364075
- CAS NO.：2403-89-6
- Empirical Formula: C10H21NO
- Molecular Weight: 171.28
- MDL number: MFCD00191220
- EINECS: 219-292-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:24:06
What is 1,2,2,6,6-Pentamethyl-4-piperidinol?
Chemical properties
LIGHT YELLOW FLAKES
The Uses of 1,2,2,6,6-Pentamethyl-4-piperidinol
1,2,2,6,6-Pentamethyl-4-piperidinol is used in the synthesis of PDGFR kinase inhibitors. Also, it can be applied to the preparation of a new diol-functionalized amine light stabilizer.
The Uses of 1,2,2,6,6-Pentamethyl-4-piperidinol
Reactant for: Synthesis of photostable blue emitting naphthalimides1 Synthesis of blue fluorescent naphthalimide pH chemosensors2 Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen3 Synthesis of spiropyrans and spirooxazines4 Amine photoredox reactions5
The Uses of 1,2,2,6,6-Pentamethyl-4-piperidinol
Reactant for:
Synthesis of photostable blue emitting naphthalimides
Synthesis of blue fluorescent naphthalimide pH chemosensors
Synthesis of crowded piperidines with intramolecularly hydrogen-bonded nitrogen
Synthesis of spiropyrans and spirooxazines
Amine photoredox reactions
What are the applications of Application
1,2,2,6,6-Pentamethyl-4-piperidinol is a building block useful for introducing a very hindered amine
Flammability and Explosibility
Non flammable
Properties of 1,2,2,6,6-Pentamethyl-4-piperidinol
| Melting point: | 72-76 °C |
| Boiling point: | 238 °C |
| Density | 0.967 |
| vapor pressure | 0.845Pa at 25℃ |
| refractive index | 1.4621 (estimate) |
| Flash point: | 118 °C |
| storage temp. | Sealed in dry,Room Temperature |
| form | Flakes |
| pka | 14.93±0.60(Predicted) |
| color | Light yellow |
| Water Solubility | 4.8 g/100 mL (20 ºc) |
| BRN | 1498 |
| CAS DataBase Reference | 2403-89-6(CAS DataBase Reference) |
| EPA Substance Registry System | 4-Piperidinol, 1,2,2,6,6-pentamethyl- (2403-89-6) |
Safety information for 1,2,2,6,6-Pentamethyl-4-piperidinol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H314:Skin corrosion/irritation H317:Sensitisation, Skin H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1,2,2,6,6-Pentamethyl-4-piperidinol
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