2,2,6,6-Tetramethyl-4-piperidinol
Synonym(s):4-Hydroxy-2,2,6,6-tetramethylpiperidine
- CAS NO.：2403-88-5
- Empirical Formula: C9H19NO
- Molecular Weight: 157.25
- MDL number: MFCD00005983
- EINECS: 219-291-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-06-04 16:00:12
What is 2,2,6,6-Tetramethyl-4-piperidinol?
Chemical properties
white to slightly beige crystalline powder
The Uses of 2,2,6,6-Tetramethyl-4-piperidinol
2,2,6,6-tetramethyl-4-piperidinol has been used to study the irradiation of Camptothecin (CPT) in aerated dimethylsulfoxide (DMSO) solution that leads to formation of singlet oxygen.
The Uses of 2,2,6,6-Tetramethyl-4-piperidinol
An intermediate in the preparation of Piperidinyloxy free radical derivatives.
Synthesis Reference(s)
The Journal of Organic Chemistry, 37, p. 2050, 1972 DOI: 10.1021/jo00977a047
Purification Methods
The piperidine crystallises from water as a hydrate and crystallises from dry ether or *C6H6 as the anhydrous base. The hydrochloride has m 282-284o (from EtOH/H2O), and the formate has m 207o(dec, from EtOH/EtOAc). [Mailey & Day J Org Chem 22 1061 1957, Beilstein 21 I 195, 21 III/IV 146, 21/1 V 159.]
Properties of 2,2,6,6-Tetramethyl-4-piperidinol
| Melting point: | 129-131 °C(lit.) |
| Boiling point: | 212-215 °C(lit.) |
| Density | 1.085 |
| refractive index | 1.4248 (estimate) |
| Flash point: | 212-215°C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | methanol: 0.1 g/mL, clear |
| pka | 14.99±0.60(Predicted) |
| form | Crystals, Crystalline Powder and/or Chunks |
| color | White to off-white or slightly beige |
| PH | 11.2 (4g/l, H2O, 20℃) |
| Water Solubility | 130 g/L (23 ºC) |
| BRN | 105039 |
| CAS DataBase Reference | 2403-88-5(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Piperidinol, 2,2,6,6-tetramethyl-(2403-88-5) |
| EPA Substance Registry System | 4-Piperidinol, 2,2,6,6-tetramethyl- (2403-88-5) |
Safety information for 2,2,6,6-Tetramethyl-4-piperidinol
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H314:Skin corrosion/irritation H317:Sensitisation, Skin |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 2,2,6,6-Tetramethyl-4-piperidinol
| InChIKey | VDVUCLWJZJHFAV-UHFFFAOYSA-N |
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