Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate

Synonym(s):TFFH

CAS NO.：164298-23-1
Empirical Formula: C5H12F7N2P
Molecular Weight: 264.12
MDL number: MFCD02684443
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-14 15:27:00

Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate Structural

What is Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate?

Chemical properties

White to off-white powder or crystal

The Uses of Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate

Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is used as a reagent for synthesis of cationic antimicrobial β-2,2-amino acid derivatives, philanthotoxin analogues for inhibition of the ionotropic glutamate receptor, small β-peptidomimetics for antimicrobials and hydrazone ligation to assemble multifunctional viral nanoparticles.

The Uses of Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate

N,N,N',N'-Tetramethylfluoroformamidinium hexafluorophosphate is a useful reagent for in situ conversion of carboxylic acids to acid fluorides. Particularly useful for the coupling of sterically hindered amino acids.

Properties of Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate

Melting point:	104-109 °C (lit.)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
form	Powder
color	Yellow
Water Solubility	Soluble in water.
CAS DataBase Reference	164298-23-1(CAS DataBase Reference)
EPA Substance Registry System	Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-) (1:1) (164298-23-1)

Safety information for Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.