Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
Synonym(s):TFFH
- CAS NO.：164298-23-1
- Empirical Formula: C5H12F7N2P
- Molecular Weight: 264.12
- MDL number: MFCD02684443
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-27 23:15:53
What is Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate?
Chemical properties
White to off-white powder or crystal
The Uses of Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate is used as a reagent for synthesis of cationic antimicrobial β-2,2-amino acid derivatives, philanthotoxin analogues for inhibition of the ionotropic glutamate receptor, small β-peptidomimetics for antimicrobials and hydrazone ligation to assemble multifunctional viral nanoparticles.
The Uses of Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
N,N,N',N'-Tetramethylfluoroformamidinium hexafluorophosphate is a useful reagent for in situ conversion of carboxylic acids to acid fluorides. Particularly useful for the coupling of sterically hindered amino acids.
Properties of Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
| Melting point: | 104-109 °C (lit.) |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| form | Powder |
| color | Yellow |
| Water Solubility | Soluble in water. |
| CAS DataBase Reference | 164298-23-1(CAS DataBase Reference) |
| EPA Substance Registry System | Methanaminium, N-[(dimethylamino)fluoromethylene]-N-methyl-, hexafluorophosphate(1-) (1:1) (164298-23-1) |
Safety information for Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate
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