1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Synonym(s):Edelfosine, 1-O-Octadecyl-2-O-methyl- rac-glycero-3-phosphorylcholine;Edelfosine, 1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphorylcholine;ET-18-OCH₃ - CAS 70641-51-9 - Calbiochem;ET-18-OCH3
- CAS NO.：70641-51-9
- Empirical Formula: C27H58NO6P
- Molecular Weight: 523.73
- MDL number: MFCD00063527
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:30
What is 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE?
The Uses of 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Edelfosine has been used to treat human lung carcinoma A549 cells and study its effects on tuftelin 1 (TUFT1) expression. It is also used to evaluate the cell growth of MCF-7/M cells.
Definition
ChEBI: 1-octadecyl-2-methylglycero-3-phosphocholine is a glycerophosphocholine that is glycero-3-phosphocholine substituted at positions 1 and 2 by octadecyl and methyl groups respectively.
General Description
Edelfosine has anti-inflammatory, anti-autoimmune, antiparasitic and anti-viral properties. It stimulates eryptosis by cell shrinkage and cell membrane scrambling.
Biochem/physiol Actions
Edelfosine is a synthetic alkyl-lisophospholipid with anti-tumor activity. The compound induces apoptosis in a variety of cancer cells. Edelfosine accumulates in the cell membrane, where it alters lipid composition and induces the co-clustering of lipid rafts and Fas/CD95 death receptor.
Storage
Store at -20°C
Properties of 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
| storage temp. | -20°C |
| solubility | ethanol: 15 mg/mL at 45 °C, soluble |
| form | waxy solid |
| color | white |
| Water Solubility | Soluble to 20 mM in water |
Safety information for 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
Computed Descriptors for 1-O-OCTADECYL-2-O-METHYL-SN-GLYCERO-3-PHOSPHOCHOLINE
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