1,2-Distearoyl-sn-glycero-3-phosphocholine
Synonym(s):PC;DSPC;PC(18:0/18:0);L -α-Phosphatidylcholine, distearoyl;L -β,γ-Distearoyl-α-lecithin
- CAS NO.：816-94-4
- Empirical Formula: C44H88NO8P
- Molecular Weight: 790.15
- MDL number: MFCD00036905
- EINECS: 212-440-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-22 22:14:22
What is 1,2-Distearoyl-sn-glycero-3-phosphocholine?
Description
1,2-Distearoyl-sn-glycero-3-PC (DSPC) is a phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.
Chemical properties
solid
The Uses of 1,2-Distearoyl-sn-glycero-3-phosphocholine
18:0 PC (DSPC) has been used:
- in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
- in the preparation of liposomes for immobilization studies
- in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery
What are the applications of Application
1,2-Distearoyl-sn-glycero-3-phosphocholine is used to produce non-pyrogenic liposome capable of caging molecules
Definition
ChEBI: A phosphatidylcholine 36:0 in which both phosphatidyl acyl groups are specified as stearoyl (octadecanoyl).
General Description
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).
Biochem/physiol Actions
1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.
Properties of 1,2-Distearoyl-sn-glycero-3-phosphocholine
| Melting point: | 236°C(lit.) |
| storage temp. | -20°C |
| solubility | slightly sol. in Chloroform |
| form | powder to crystal |
| color | White to Almost white |
| BRN | 3923978 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
Safety information for 1,2-Distearoyl-sn-glycero-3-phosphocholine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P201:Obtain special instructions before use. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for 1,2-Distearoyl-sn-glycero-3-phosphocholine
| InChIKey | NRJAVPSFFCBXDT-HUESYALOSA-N |
| SMILES | [C@H](OC(=O)CCCCCCCCCCCCCCCCC)(COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCCCC |&1:0,r| |
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