ZL0454
- CAS NO.：2229042-77-5
- Empirical Formula: C18H22N4O3S
- Molecular Weight: 374.46
- MDL number: MFCD31813659
- Update Date: 2026-04-22 18:57:36
What is ZL0454?
Biological Activity
ZL0454 is a potent and selective Bromodomain-containing protein 4 (BRD4) inhibitor with an IC50 of 49 and 32 nM for BD1 and BD2.
References
[1]. Liu Z, et al. Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation. Eur J Med Chem. 2018 May 10;151:450-461.
Properties of ZL0454
| Boiling point: | 630.6±65.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (133.53 mM; Need ultrasonic) |
| pka | 9.30±0.36(Predicted) |
| form | Solid |
| color | Brown to reddish brown |
Safety information for ZL0454
Computed Descriptors for ZL0454
New Products
3-AMINO-3-(2-FLUORO-PHENYL)-PROPIONIC ACID Pentadecanoic acid Hendecanoic acid 2-AMINO-3-METHYLQUINOLINE HYDROCHLORIDE 3-Hydroxypropionitrile DL-3-Amino-3-(2-methoxyphenyl)propionic acid 2-Bromo-5-Iodopyridine 2,3-Diamino-5-Chloropyridine 2-Amino-3-Hydroxypyridine 2,6-Diamino Pyridine 4-Amino-2-Chloropyridine 2-Hydroxy-4-Picoline 4-(4-(Dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hydroxymethyl)benzonitrile 2-Hydroxy-5-methoxybenzoic acid 2-Cyanopyrimidine Xanthene-9-carboxylic acid 4,4-Diethoxybutanenitrile Methyl 4-amino-2,3-difluoro-5-nitrobenzoate 5-fluoro-1,3-benzodioxole 5-Phenyl-[1,3,4]-thiadiazol-2-amine 2-Chloro-6-nitro benzothiazole 4-Chloro-2-methyl quinoline 2-Amino-4-phenyl-thiazole 2-(Chloromethyl) quinazolin-4(3H)-oneRelated products of tetrahydrofuran
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