ZLN005

Synonym(s):2-(4-tert-Butylphenyl)-1H-benzimidazole;2-[4-(1,1-Dimethylethyl)phenyl]-1H-benzimidazole

CAS NO.：49671-76-3
Empirical Formula: C17H18N2
Molecular Weight: 250.34
MDL number: MFCD01560221
SAFETY DATA SHEET (SDS)
Update Date: 2026-02-02 18:10:39

What is ZLN005?

Description

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a tissue-specific and inducible transcriptional coactivator for several nuclear receptors and plays a key role in energy metabolism, hepatic gluconeogenesis, and cholesterol homoeostasis. ZLN005 is a small molecule that stimulates the expression of PGC-1α and downstream genes in skeletal muscle cells, improving glucose utilization and fatty acid oxidation at a concentration of 20 μM. Chronic administration of 15 mg/kg/day ZLN005 to diabetic db/db mice increased PGC-1α and downstream gene transcription in skeletal muscle, increasing fat oxidation and improving glucose tolerance, pyruvate tolerance, and insulin sensitivity.

The Uses of ZLN005

ZLN005 increaces PGC-1α and downstream gene transcription in skeletal muscles and increases fat oxidation and improved the glucose tolerance, pyruvate tolerance, and insulin sensitivity of diabetic db/db mice.

Properties of ZLN005

Melting point:	257-258℃
Boiling point:	415.3±38.0 °C(Predicted)
Density	1.102±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: soluble10mg/mL, clear
pka	11.52±0.10(Predicted)
form	powder
color	white to beige

Safety information for ZLN005

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H319:Serious eye damage/eye irritation H413:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.