TYR-GLY-SER-LEU-PRO-GLN-LYS-SER-GLN-ARG-SER-GLN-ASP-GLU-ASN

Biological Activity

myelin basic protein (68-82), guinea pig,(c71h113n23o28) is a peptide with the sequence tyr-gly-ser-leu-pro-gln-lys-ser-gln-arg-ser-gln-asp-glu-asn, mw= 1736.79. myelin basic protein (mbp) is a protein believed to be important in the process of myelination of nerves in the nervous system. knockout mice deficient in mbp showed decreased amounts of cns myelination and have developed a progressive disorder characterized by tremors, seizures, and early death. mbp research has centered on its role in demyelinating diseases, in particular, multiple sclerosis (ms). several studies have uncovered the role of antibodies against mbp in the pathogenesis of ms.] some studies have linked a genetic predisposition to ms to the mbp gene, though a majority have not. some recent work has shown that inoculating an animal with mbp to generate an immune response against it increases blood–brain barrier permeability.figure1 formula of myelin basic protein (68-82), guinea pigfigure2 structure of myelin basic protein

Biochem/physiol Actions

Myelin basic protein fragment that induces experimental allergic encephalomyelitis.

References

1. Sakamoto Y, Kitamura K, Yoshimura K, Nishijima T, Uyemura K (March 1987). "Complete amino acid sequence of POprotein in bovine peripheral nerve myelin". J. Biol. Chem. 262 (9): 4208–14.2. Deber CM, Reynolds SJ (April 1991). "Central nervous system myelin: structure, function, and pathology". Clin. Biochem. 24 (2): 113–34.3. Inouye H, Kirschner DA (January 1991). "Folding and function of the myelin proteins from primary sequence data". J. Neurosci. Res. 28 (1): 1–17.4. Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, Dilitz E, Deisenhammer F, Reindl M (July 2003). "Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event". N. Engl. J. Med. 349 (2): 139–45.