thonzylamine

Toxicity

Doses of up to 300 mg/day for up to 4 days have produces no observable toxic effects in humans . In a chronic toxicity study, rats were given up to 200 mg/kg/day orally for 91 days with no observable toxic effects .

The Uses of thonzylamine

Thonzylamine is a selective H1-histamine receptor anatagonists. Tropine esterase inhibitor.

Background

Thonzylamine is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhinitis) or other upper respiratory allergies.

Indications

Thozylamine is indicated for use in the symptomatic control of allergic rhinitis or other upper respiratory allergic symptoms . It is typically a part of combination over the counter products.

Definition

ChEBI: N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-(2-pyrimidinyl)ethane-1,2-diamine is a member of methoxybenzenes.

General Description

An oily liquid. Used (in the form of the hydrochloride) as an antihistaminic.

Reactivity Profile

thonzylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products.

Pharmacokinetics

Thonzylamine is a first-generation antihistamine. It antagonizes the action of histamine to relief allergic symptoms like nasal congestion, runny nose, itchy eyes, itchy nose and throat, and sneezing

Synthesis

Thonzylamine is synthesized by treating the sodium salt of 2-(4-methoxybenzyl)aminopyrimidine with N,N-dimethyl-2-chloroethylamine .

Metabolism

Not Available