SMER 3

Synonym(s):9H-Indeno-[1,2-e]-[1,2,5]-oxadiazolo-[3,4-b]-pyrazin-9-one

CAS NO.：67200-34-4
Empirical Formula: C11H4N4O2
Molecular Weight: 224.18
MDL number: MFCD00451458
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is SMER 3?

Description

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)^MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCF^MET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.

The Uses of SMER 3

SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.

Definition

ChEBI: LSM-42773 is an aromatic ketone.

Storage

Store at +4°C

References

1) Aghajanyy et al. (2010), Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor; Nat. Biotechnol., 28 738

Properties of SMER 3

Melting point:	283-284 °C(Solv: ethanol (64-17-5))
Boiling point:	437.2±55.0 °C(Predicted)
Density	1.665±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥30mg/mL
pka	-8.15±0.20(Predicted)
form	powder
color	yellow
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.