SCIADOPITYSIN
- CAS NO.：521-34-6
- Empirical Formula: C33H24O10
- Molecular Weight: 580.54
- MDL number: MFCD00017448
- EINECS: 208-311-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-27 17:00:41
What is SCIADOPITYSIN?
Description
Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities. It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; ) in PC12 cells (EC50 = 9.84 μM). Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells. It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel in MDR1-MDCKII cells. Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.
Definition
ChEBI: A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.
Properties of SCIADOPITYSIN
| Melting point: | 296-298°C |
| Boiling point: | 839.6±65.0 °C(Predicted) |
| Density | 1.445±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in ethanol and methan |
| form | powder |
| pka | 6.16±0.40(Predicted) |
| color | Light yellow |
| CAS DataBase Reference | 521-34-6 |
Safety information for SCIADOPITYSIN
Computed Descriptors for SCIADOPITYSIN
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