2,2'-Biphenol

Synonym(s):2,2′-Biphenyldiol;2,2′-Dihydroxybiphenyl;2,2′-Diphenol;Biphenyl-2,2′-diol;o,o′-Biphenol, 2,2′-Dihydroxydiphenyl

CAS NO.：1806-29-7
Empirical Formula: C12H10O2
Molecular Weight: 186.21
MDL number: MFCD00002210
EINECS: 217-303-0
SAFETY DATA SHEET (SDS)
Update Date: 2025-10-21 20:59:21

What is 2,2'-Biphenol?

Chemical properties

Beige to greyish-beige powder

The Uses of 2,2'-Biphenol

2,2'-Dihydroxybiphenyl, is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Definition

ChEBI: A member of the class of hydroxybiphenyls carrying hydroxy groups at positions 2 and 2'.

Production Methods

2,2'-Dihydroxybiphenyl is obtained by alkaline fusion of biphenylene oxide at ca. 300 ℃ (sometimes catalyzed by fluorene or carbazole) or by debutylation of 3,3',5,5'-tetra-tert-butyl-2,2'-dihydroxybiphenyl, which itself is produced by the oxidative coupling of 2,4-di-tert-butylphenol. 2,2'-Dihydroxy-5,5'-dimethylbiphenyl can be synthesized accordingly.

Safety Profile

Poison by intraperitoneal andintravenous routes. Human mutation data reported. Whenheated to decomposition it emits acrid smoke andirritating fumes.

Purification Methods

Crystallise the biphenyl repeatedly from toluene, then sublime it at 60o/10-4mm. [Beilstein 6 IV 6645.]

Properties of 2,2'-Biphenol

Melting point:	108-110 °C
Boiling point:	315 °C(lit.)
Density	0.83
refractive index	1.6086 (estimate)
Flash point:	154 °C
storage temp.	Store below +30°C.
form	Powder
pka	7.32±0.10(Predicted)
color	Beige to grayish-beige
Water Solubility	insoluble
BRN	1638363
CAS DataBase Reference	1806-29-7(CAS DataBase Reference)
NIST Chemistry Reference	[1,1'-Biphenyl]-2,2'-diol(1806-29-7)
EPA Substance Registry System	2,2'-Biphenol (1806-29-7)

Safety information for 2,2'-Biphenol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H301:Acute toxicity,oral H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see … on this label). P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..…