4'-Hydroxy-3'-methylacetophenone
- CAS NO.：876-02-8
- Empirical Formula: C9H10O2
- Molecular Weight: 150.17
- MDL number: MFCD00002231
- EINECS: 212-880-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-06-19 14:53:15
What is 4'-Hydroxy-3'-methylacetophenone?
Chemical properties
white to light beige crystalline powder or
The Uses of 4'-Hydroxy-3'-methylacetophenone
4''-Hydroxy-3''-methylacetophenone is used in the synthesis of 3-De(hydroxymethyl)-3-methyl Salmeterol (D230650), which is an impurity of β2-Adrenergic agonist Salmeterol (S090100).
Preparation
Preparation by dealkylation of 4-hydroxy-5-methyl-2-iso-propylacetophenone with aluminium chloride in chloro-benzene at 50° (53%).
Definition
ChEBI: 4-hydroxy-3-methylacetophenone is a monohydroxyacetophenone that is acetophenone carrying methyl and hydroxy groups at positions 3 and 4, respectively. It has a role as a volatile oil component and an insect attractant. It is a monohydroxyacetophenone, a member of phenols and a hydroxytoluene. It is functionally related to an acetophenone.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 23, p. 738, 1980 DOI: 10.1021/jm00181a008
Properties of 4'-Hydroxy-3'-methylacetophenone
| Melting point: | 107-109 °C(lit.) |
| Boiling point: | 175°C 1mm |
| Density | 1.0858 (rough estimate) |
| refractive index | 1.5180 (estimate) |
| Flash point: | 175°C/1mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 8.52±0.18(Predicted) |
| color | Off-White to Pale Beige |
| BRN | 2041839 |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 876-02-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 4-Hydroxy-3-methylacetophenone(876-02-8) |
Safety information for 4'-Hydroxy-3'-methylacetophenone
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4'-Hydroxy-3'-methylacetophenone
4'-Hydroxy-3'-methylacetophenone manufacturer
ASM Organics
Andhra Pradesh
Phone:91-9866122393
Whatsapp: 91-9866122393
product: 4'-Hydroxy-3'-Methyl Acetophenone
New Products
(E)-1-Ethoxyethene-2-boronic Acid Pinacol Ester 1,3-Diethyl-1,3-Diphenylurea 3-(4-morpholinophenylamino)-5-amino-1H-pyrazole-4-carbonitrile Methyl 2-methylquinoline-6-carboxylate 2,4-dihydroxybenzaldehyde 2-((4-morpholinophenylamino) (methylthio) methylene) malononitrile 1,3-Di Iodo Benzene Methyl 2-oxo-2,3-dihydrobenzo[d]oxazole-7-carboxylate 4-(2-Aminoethyl)-7-hydroxy-2H-chromoen-2-one 3-Hydroxy-4-nitrobromobenzene 2-Ethyl-1,4-diaminobenzene 2-Ethylhexyl 4-aminobenzoate Thio AcetamideRelated products of tetrahydrofuran
You may like
-
876-02-8 4'- Hydroxy- 3'-methyl acetophenone 98%View Details
876-02-8 -
876-02-8 98%View Details
876-02-8 -
4'-Hydroxy-3'-methylacetophenone 98%View Details
876-02-8 -
149105-11-3 876-02-8 1-(4-hydroxy-3-methylphenyl) ethanone 98%View Details
149105-11-3 876-02-8 -
4'-Hydroxy-3'-Methyl Acetophenone 98%View Details -
876-02-8 98%View Details
876-02-8 -
876-02-8 99%View Details
876-02-8 -
4'-Hydroxy-3'-methylacetophenone CAS 876-02-8View Details
876-02-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.