POBN
Synonym(s):N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide;N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide;POBN
- CAS NO.：66893-81-0
- Empirical Formula: C10H14N2O2
- Molecular Weight: 194.23
- MDL number: MFCD00041022
- EINECS: 266-512-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:57:00
What is POBN?
Chemical properties
white to pale yellow crystalline powder
The Uses of POBN
Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.
The Uses of POBN
POBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide.
What are the applications of Application
POBN is a cell permeable hydrophilic spin trap
Properties of POBN
| Melting point: | 183-185 °C(lit.) |
| Boiling point: | 330.68°C (rough estimate) |
| Density | 1.1444 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| storage temp. | room temp |
| solubility | water: soluble10mg/mL, clear, colorless to faintly yellow |
| form | White to off-white or colorless crystalline solid. |
| pka | 0.76±0.53(Predicted) |
| color | White to Light yellow |
| BRN | 1453764 |
Safety information for POBN
Computed Descriptors for POBN
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide 4-Nitrobenzotrifluoride 2-Pentyn-1-oLRelated products of tetrahydrofuran
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