4,4'-DIPYRIDYL DISULFIDE
Synonym(s):4,4′-Dipyridyl disulfide;4,4′-Dithiodipyridine
- CAS NO.：2645-22-9
- Empirical Formula: C10H8N2S2
- Molecular Weight: 220.31
- MDL number: MFCD00006423
- EINECS: 220-158-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-09-09 10:27:52
What is 4,4'-DIPYRIDYL DISULFIDE?
Chemical properties
white to orange crystalline powder
The Uses of 4,4'-DIPYRIDYL DISULFIDE
- Aldrithiol?-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
- It was used to study the O2 equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
- It was used to modify gold surfaces for protein studies.
What are the applications of Application
4,4′-dipyridyl disulfide is used to modify gold surfaces for protein studies
Definition
ChEBI: An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine.
Purification Methods
Recrystallise the disulfide from H2O, EtOH, Me2CO, *C6H6 or pet ether. It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 4-mercaptopyridine (4-pyridinethiol) anion, thereby shifting the max from 324nm (of the disulfide) to 285nm (of the anion) at pH 9. (Compare with 2,2’dipyridyl disulfide above which has been used for the same purpose.) [Humphrey et al. Anal Chem 40 698 1970, Cheng & Ritchie Aust J Chem 26 1785 1973.] [Beilstein 21 II 35, for review see Aldrichimica Acta 4 33 1971.]
Properties of 4,4'-DIPYRIDYL DISULFIDE
| Melting point: | 76-78 °C(lit.) |
| Boiling point: | 356.1±17.0 °C(Predicted) |
| Density | 1.3078 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | 2-8°C |
| solubility | 95% ethanol: soluble5%, clear, colorless to light yellow |
| form | Crystalline Powder |
| pka | 3.60±0.26(Predicted) |
| color | White to orange |
| BRN | 154742 |
| CAS DataBase Reference | 2645-22-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyridine, 4,4'-dithiobis-(2645-22-9) |
Safety information for 4,4'-DIPYRIDYL DISULFIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4,4'-DIPYRIDYL DISULFIDE
| InChIKey | UHBAPGWWRFVTFS-UHFFFAOYSA-N |
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