4-acetamidobenzoic acid

Synonym(s):N-Acetyl-PABA

CAS NO.：556-08-1
Empirical Formula: C9H9NO3
Molecular Weight: 179.17
MDL number: MFCD00002534
EINECS: 209-114-7
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-12 09:20:59

What is 4-acetamidobenzoic acid?

Chemical properties

white or off-white powder or crystals

Originator

4-Acetamidobenzoic acid ,ARIAC

The Uses of 4-acetamidobenzoic acid

immune stimulant (component)

The Uses of 4-acetamidobenzoic acid

Acedoben is the acetylated derivative of p-aminobenzoic acid (PABA). Acedoben is a metabolite of the anesthetic Benzocaine (B202970).

What are the applications of Application

4-Acetamidobenzoic Acid is an acetylated derivative of p-aminobenzoic acid (PABA)

Definition

ChEBI: A amidobenzoic acid that consists of benzoic acid bearing an acetamido substituent at position 4.

Manufacturing Process

Into a 2 L, 3-necked flask set in a tub and equipped with a stirrer, an air condenser (drying tube), thermometer, was placed 860 ml of water, 43.0 g of MgSO4 and 43.0 g of sodium acetate and heated on water bath. Into heated solution to 70°C stirring 43.0 g of N-p-tolylacetamide were added. Then 136.0 g of KMnO4 by small portions were added at 75°-80°C. The reaction mixture allow to stand for 6 h and stirring was continue till the solution became colorless. Hot solution was filtered and filtrate treated hydrochloric acid to slightly acidic pH. After that 44.0 g (85%) of p-acetoaminobenzoic acid was obtained as white precipitate, melting point 250°C.

Therapeutic Function

Antiviral

General Description

Needles or off-white powder.

Air & Water Reactions

Water insoluble.

Reactivity Profile

Simultaneously an amide and a carboxylic acid.

Fire Hazard

Flash point data for p-Acetylamino benzoic acid are not available; however, p-Acetylamino benzoic acid is probably combustible.

Properties of 4-acetamidobenzoic acid

Melting point:	259-262 °C (dec.)(lit.)
Boiling point:	311.69°C (rough estimate)
Density	1.2822 (rough estimate)
refractive index	1.5600 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Powder
pka	pK1: 4.28 (25°C)
color	Off-white to slightly beige
Water Solubility	<0.1 g/100 mL at 21 ºC
BRN	390602
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	556-08-1(CAS DataBase Reference)
NIST Chemistry Reference	N-(4-Carboxyphenyl)acetic acid amide(556-08-1)
EPA Substance Registry System	Benzoic acid, 4-(acetylamino)- (556-08-1)

Safety information for 4-acetamidobenzoic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.