4-Acetylbenzoic acid

Chemical properties

White to light yellow crystal powder

The Uses of 4-Acetylbenzoic acid

4-Acetylbenzoic acid was used in the preparation of an ester-derivative of paclitaxel.

Synthesis Reference(s)

Synthesis, p. 715, 1974 DOI: 10.1055/s-1974-23412

Purification Methods

4-AcDissolve the acid in 5% aqueous NaOH, extract it with Et2O, and acidify the aqueous solution. Collect the precipitate, and recrystallise it from boiling H2O (100 parts) using decolorising charcoal [Pearson et al. J Org Chem 24 504 1959, Pearson et al. J Chem Soc 265 1957, Detweiler & Amstutz J Am Chem Soc 72 2882 1950, Bordwell & Cooper J Am Chem Soc 74 1058 1952]. [Beilstein 10 IV 2769.]