N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- CAS NO.：477600-74-1
- Empirical Formula: C13H19N5
- Molecular Weight: 245.32
- MDL number: MFCD09878608
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-05-28 00:53:20
![N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Structural](https://img.chemicalbook.in/CAS/GIF/477600-74-1.gif)
What is N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine?
Description
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is an important pharmaceutical intermediate that is a by-product of the preparation of tofacitinib. Tofacitinib belongs to a class of Janus kinase (JAK) inhibitors used in the treatment of rheumatoid arthritis and psoriatic arthritis.
The Uses of N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
N-Methyl-N-((3S,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, is an intermediate in the synthesis of (3S,4R)-Tofacitinib (T528010), an enantiopure stereoisomer of the drug, Janus kinase 3(Jak3) inhibitor (CP-690,550) that has been found to inhibit selected members of the STE7 and STE20 subfamily of kinases.
Properties of N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
| Melting point: | 157 - 162°C |
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Aqueous Acid (Slightly), Methanol (Slightly), Water (Slightly, Heated) |
| form | Solid |
| pka | 13.36±0.50(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C13H19N5/c1-9-3-5-14-7-11(9)18(2)13-10-4-6-15-12(10)16-8-17-13/h4,6,8-9,11,14H,3,5,7H2,1-2H3,(H,15,16,17)/t9-,11+/m1/s1 |
Safety information for N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
| InChIKey | XRIARWQZLGCQDM-KOLCDFICSA-N |
| SMILES | C1=NC(N(C)[C@@H]2[C@H](C)CCNC2)=C2C=CNC2=N1 |
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine manufacturer
Vidgas Science & Technologies Pvt Ltd
3Y
Phone:+91-9030019844
Whatsapp: +91-9030019844
product: 477600-74-1 ABOVE 99%
New Products
2-Amino-5-bromo-4-(trifluoromethyl)pyridine Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde β-Bromostyrene Ethyl 3-phenylpropanoate Phenethyl cinnamate Dipropyl disulfide N-Vinylformamide 4 pentyn 1 ol Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
![4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE](https://img.chemicalbook.in/CAS/GIF/479633-63-1.gif)
![7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-](https://img.chemicalbook.in/CAS/20150408/GIF/923036-30-0.gif)
![7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-](https://img.chemicalbook.in/CAS/GIF/477600-73-0.gif)
![4-Chloro-7H-pyrrolo[2,3-d]pyrimidine](https://img.chemicalbook.in/CAS/GIF/3680-69-1.gif)
![3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI)](https://img.chemicalbook.in/CAS/20150408/GIF/477600-76-3.gif)
![3-((3R,4R)-3-((2-chloro-7H-pyrrolo[2,3-d]pyriMidin-4-yl)(Methyl)aMino)-4-Methylpiperidin-1-yl)-3-oxopropanenitrile](https://img.chemicalbook.in/CAS/20150408/GIF/CB32667507.gif)
You may like
-
![477600-74-1 (3R,4R)-Methyl-(4-methyl-piperidin-3-yl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 99%](https://img.chemicalbook.in//ProductImageIndia/2024-03/Raw/9772f8a7-c63f-41cd-92c6-74dd1e411de3.png)
477600-74-1 (3R,4R)-Methyl-(4-methyl-piperidin-3-yl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine 99%View Details
477600-74-1 -
![N-Methyl-n-((3r,4r)-4-methylpiperidin-3-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine 95% CAS 477600-74-1](https://img.chemicalbook.in//Content/image/CP5.jpg)
N-Methyl-n-((3r,4r)-4-methylpiperidin-3-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine 95% CAS 477600-74-1View Details
477600-74-1 -
477600-74-1 90 % AboveView Details
477600-74-1 -
Tofacitinib Impurity-M (Debenzylated)View Details
477600-74-1 -
Tofacitinib Amine Impurity, Analytical GradeView Details
477600-74-1 -
477600-74-1 ABOVE 99%View Details
477600-74-1 -
Fmoc-OSu 98+View Details
82911-69-1 -
(R)-(-)-2-Amino-1-propanol 35320-23-1 98+View Details
35320-23-1
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.