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HomeProduct name list4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

  • CAS NO.：479633-63-1
  • Empirical Formula: C13H10ClN3O2S
  • Molecular Weight: 307.76
  • MDL number: MFCD09907939
  • EINECS: 811-000-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2026-05-28 01:03:46
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine Structural

What is 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine?

The Uses of 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine is a reagent in the synthesis of (+)-tofacitinib, a selective Janus kinase 3 inhibitor (JAK3) and an immunosuppressant drug.

Synthesis

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine (2kg, 12.96mol) and dichloromethane (40L) were added to the reaction flask at room temperature, stirred and dissolved. Triethylamine (3.88 kg, 38.4 mol) and 4-dimethylamino pyridine (157.6 g, 1.28 mol) were added in that order, and after stirring and dissolved, p-toluenesulfonyl chloride (2.6 kg, 13.6 mol) was added dropwise at 0 °C. The chloromethane (30 L) solution was added dropwise, and the mixture was stirred at room temperature for 30 min. After the TLC was applied, the mixture was washed with water (16L×3). 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (3.9 kg, yield 97.7%) was obtained after drying under reduced pressure.
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Properties of 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Melting point: 145.0 to 149.0 °C
Boiling point: 505.3±60.0 °C(Predicted)
Density  1.49
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), DMSO (Slightly)
form  powder to crystal
pka 1.73±0.30(Predicted)
color  White to Orange to Green
InChI InChI=1S/C13H10ClN3O2S/c1-9-2-4-10(5-3-9)20(18,19)17-7-6-11-12(14)15-8-16-13(11)17/h2-8H,1H3

Safety information for 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for 4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine

InChIKey BTOJSYRZQZOMOK-UHFFFAOYSA-N
SMILES C1=NC(Cl)=C2C=CN(S(C3=CC=C(C)C=C3)(=O)=O)C2=N1

4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine manufacturer

Vidgas Science & Technologies Pvt Ltd

3Y
Phone:+91-9030019844
Whatsapp: +91-9030019844
product: 4-chloro-7-tosyl-7-H-pyrrolo[2,3- d]pyrimidine 479633-63-1 ABOVE 99%
Inquiry

HESTUR PHARMA PRIVATE LIMITED

1Y
Phone:+919966969147
Whatsapp: +91-9966969147
product: 479633-63-1 4-Chloro-7-tosy1-7Hpyrrolo[2,3-d]pyrimidine 99%
Inquiry

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