4-Aminopyrazolo[3,4-d]pyrimidine
Synonym(s):1H-Pyrazolo[3,4-d]pyrimidine-4-ylamine;4-Amino-1H-pyrazolo[3,4-d]pyrimidine
- CAS NO.：2380-63-4
- Empirical Formula: C5H5N5
- Molecular Weight: 135.13
- MDL number: MFCD00005688
- EINECS: 219-174-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-03-13 09:27:42
![4-Aminopyrazolo[3,4-d]pyrimidine Structural](https://img.chemicalbook.in/CAS/GIF/2380-63-4.gif)
What is 4-Aminopyrazolo[3,4-d]pyrimidine?
Description
4-aminopyrazolo[3,4-d]pyrimidine (4-APP), the isomer of adenine with the five-membered ring in the pyrazole configuration, is by far the most potent inhibitor of both enzymatic reactions catalyzed by Stx1. It is also a new type of mTOR inhibitor. The 4-aminopyrazolo[3,4-d]pyrimidines, a well-characterized class of compounds for tyrosine kinase inhibition, were used as a Src inhibitor module that blocks the adenosine binding site[1-2].
Chemical properties
Light Tan Solid
The Uses of 4-Aminopyrazolo[3,4-d]pyrimidine
4-Amino-1H-pyrazolo[3,4-d]pyrimidine decreases serum cholesterol markedly in rats.
What are the applications of Application
4-Aminopyrazolo[3,4-d]pyrimidine is a heterocycle used for research purposes
References
[1] M Brigotti. “4-Aminopyrazolo[3,4-d]pyrimidine (4-APP) as a novel inhibitor of the RNA and DNA depurination induced by Shiga toxin 1.” Nucleic Acids Research 28 12 (2000): 2383–8.
[2] Ho Jin Lee. “Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.” Molecular Cancer 17 1 (2018): 50.
Properties of 4-Aminopyrazolo[3,4-d]pyrimidine
| Melting point: | >325 °C(lit.) |
| Boiling point: | 238.81°C (rough estimate) |
| Density | 1.3795 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | soluble in DMSO |
| pka | 12.12±0.20(Predicted) |
| form | powder to crystal |
| color | White to Orange to Green |
| Water Solubility | Insoluble in water. |
| BRN | 5824 |
| CAS DataBase Reference | 2380-63-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-pyrazolo[3,4-d]pyrimidin-4-amine(2380-63-4) |
| EPA Substance Registry System | 1H-Pyrazolo[3,4-d]pyrimidin-4-amine (2380-63-4) |
Safety information for 4-Aminopyrazolo[3,4-d]pyrimidine
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see … on this label). P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 4-Aminopyrazolo[3,4-d]pyrimidine
| InChIKey | LHCPRYRLDOSKHK-UHFFFAOYSA-N |
4-Aminopyrazolo[3,4-d]pyrimidine manufacturer
Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group)
Maharashtra
product: 4-Amino-1H-pyrazolo[3,4-d]pyrimidine
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