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HomeProduct name listMethyl 3-amino-4-methylthiophene-2-carboxylate

Methyl 3-amino-4-methylthiophene-2-carboxylate

Synonym(s):3-Amino-4-methylthiophenecarboxylic acid methyl ester

  • CAS NO.:85006-31-1
  • Empirical Formula: C7H9NO2S
  • Molecular Weight: 171.22
  • MDL number: MFCD00051822
  • EINECS: 285-060-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-17 21:30:02
Methyl 3-amino-4-methylthiophene-2-carboxylate Structural

What is Methyl 3-amino-4-methylthiophene-2-carboxylate?

Chemical properties

white to light yellow crystal powder

The Uses of Methyl 3-amino-4-methylthiophene-2-carboxylate

Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.

Definition

ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid.

Methyl 3-amino-4-methylthiophene-2-carboxylate Application

methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.

Properties of Methyl 3-amino-4-methylthiophene-2-carboxylate

Melting point: 85-88 °C (lit.)
Boiling point: 318.6±37.0 °C(Predicted)
Density  1.264±0.06 g/cm3(Predicted)
Flash point: >100°C
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 1.71±0.10(Predicted)
color  Pale Yellow
Water Solubility  1g/L at 35℃
BRN  973196
CAS DataBase Reference 85006-31-1(CAS DataBase Reference)
NIST Chemistry Reference Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)

Safety information for Methyl 3-amino-4-methylthiophene-2-carboxylate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Methyl 3-amino-4-methylthiophene-2-carboxylate

InChIKey YICRPERKKBDRSP-UHFFFAOYSA-N

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