Methyl 3-amino-4-methylthiophene-2-carboxylate

Synonym(s):3-Amino-4-methylthiophenecarboxylic acid methyl ester

CAS NO.：85006-31-1
Empirical Formula: C7H9NO2S
Molecular Weight: 171.22
MDL number: MFCD00051822
EINECS: 285-060-8
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-27 17:21:19

Methyl 3-amino-4-methylthiophene-2-carboxylate Structural

What is Methyl 3-amino-4-methylthiophene-2-carboxylate?

Chemical properties

white to light yellow crystal powder

The Uses of Methyl 3-amino-4-methylthiophene-2-carboxylate

Methyl 3-Amino-4-methylthiophene-2-carboxylate is a versatile reactant used in various syntheses. It is used in the preparation of (oxalylamino)benzoic acids and (carboxyheteroarylamino)oxalic acids as selective and orally bioavailable nonpeptide inhibitors of protein-tyrosine phosphatase 1B.

Definition

ChEBI: Methyl 3-amino-4-methylthiophene-2-carboxylate is a thiophenecarboxylic acid.

Methyl 3-amino-4-methylthiophene-2-carboxylate Application

methyl 3-amino-4-methylthiophene-2-carboxylate is the starting material used in the synthesis of the local anesthetic articaine.7-Methylthieno[3,2-d]pyrimidin-4(3H)-one was prepared using methyl 3-amino-4-methylthiophene-2-carboxylate.The reaction of 4-bromotoluene (0.171 g, 1 mmol), methyl 3-amino-4-methylthiophene-2-carboxylate(0.342 g, 2 mmol) and KOAc (0.196 g, 2 mmol) in the presence of PdCl(C3H5)(dppb) (12.2 mg, 0.02mmol) in DMAc at 120 °C affords the corresponding Methyl 3-amino-4-methyl-5-p-tolylthiophene-2-carboxylate in 81% (0.212 g) isolated yield.

Properties of Methyl 3-amino-4-methylthiophene-2-carboxylate

Melting point:	85-88 °C (lit.)
Boiling point:	318.6±37.0 °C(Predicted)
Density	1.264±0.06 g/cm3(Predicted)
Flash point:	>100°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	1.71±0.10(Predicted)
color	Pale Yellow
Water Solubility	1g/L at 35℃
BRN	973196
CAS DataBase Reference	85006-31-1(CAS DataBase Reference)
NIST Chemistry Reference	Methyl 3-amino-4-methylthiophene-2-carboxylate(85006-31-1)

Safety information for Methyl 3-amino-4-methylthiophene-2-carboxylate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.