LY3214996

CAS NO.：1951483-29-6
Empirical Formula: C22H27N7O2S
Molecular Weight: 453.56
MDL number: MFCD31544324
Update Date: 2026-07-27 17:00:41

What is LY3214996?

Description

LY3214996 is an inhibitor of ERK1 and ERK2 (IC₅₀ = 5 nM for both). It inhibits cell proliferation of tumor cells in vitro, including those expressing B-RAF, N-Ras, or K-Ras mutations. LY3214996 inhibits tumor growth in B-RAF or N-Ras mutant melanoma, B-RAF or K-Ras mutant colorectal, lung, and pancreatic cancer mouse xenograft models, as well as patient-derived xenograft (PDX) mouse models.

Properties of LY3214996

Boiling point:	711.5±70.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:23.5(Max Conc. mg/mL);51.81(Max Conc. mM) Ethanol:16.0(Max Conc. mg/mL);35.28(Max Conc. mM)
form	A crystalline solid
pka	6.58±0.10(Predicted)
color	White to yellow

Safety information for LY3214996

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.