LY-3177833
- CAS NO.：1627696-51-8
- Empirical Formula: C16H12FN5O
- Molecular Weight: 309.3
- MDL number: MFCD30533280
- Update Date: 2025-10-29 15:43:00
What is LY-3177833?
Description
LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.
Properties of LY-3177833
| Boiling point: | 660.7±55.0 °C(Predicted) |
| Density | 1.398±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.67±0.40(Predicted) |
| color | White to off-white |
Safety information for LY-3177833
Computed Descriptors for LY-3177833
New Products
DL-beta-(3-Bromophenyl)alanine 1-Aminocyclopentane carbonitrile (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid N,N CARBONYL DIIMIDAZOLE 2-Amino-5-bromo-4-(trifluoromethyl)pyridine（RM for Indian lab) Benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate Amlodipine EP Impurity-C Budesonide Impurity-K/Budesonide 21-Acetate (Epimers) Gabapentine Impurity 72 Bicalutamide Impurity-B Betahistine EP Impurity C Carbamazepine EP Impurity G 2,2'-(5-methyl-1,3-phenylene)-di(2-Methylpropionitrile) 4-Fluorothiophenol 1-methyl amino-2,4-dinitro benzene 5-Methyl-1,3-benzenediacetonitrile (R)-BoroLeu-(+)-Pinanediol-CF3COOH 4-(5-amino-1-methyl-1h-benzoimidazol-2-yl)-butyric acid isopropyl ester. 3-Hydroxypropionitrile 4-Bromo Benzylcyanide valeronitrile 3,4 Dimethoxy Benzylcyanide 3-chlorobenzyl cyanide 2-Chloro BenzylcyanideRelated products of tetrahydrofuran
![Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2](https://img.chemicalbook.in/CAS/20211123/GIF/1088715-84-7.gif)
You may like
-
Bendamustine deschloroethyl acid ethyl ester NLT 95%View Details
2517968-40-8 -
110-59-8 valeronitrile 99%View Details
110-59-8 -
93-17-4 99%View Details
93-17-4 -
4-Bromo Benzylcyanide 99%View Details
26451-08-1 -
3-Hydroxypropionitrile 109-78-4 99%View Details
109-78-4 -
1529-41-5 3-chlorobenzyl cyanide 99%View Details
1529-41-5 -
2856-63-5 99%View Details
2856-63-5 -
3,4 Diethoxy Benzylcyanide 99%View Details
27472-21-5
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.