LY-3177833
- CAS NO.：1627696-51-8
- Empirical Formula: C16H12FN5O
- Molecular Weight: 309.3
- MDL number: MFCD30533280
- Update Date: 2026-05-28 06:29:31
What is LY-3177833?
Description
LY3177833 is an orally bioavailable inhibitor of Cdc7 kinase (IC50 = 3.3 nM for ADP production in an enzyme assay). It inhibits phosphorylation of MCM2-S53 in H1299 cells (IC50 = 0.29 μM). LY3177833 reduces tumor growth in an SW620 human colorectal adenocarcinoma mouse xenograft model when administered at doses of 10, 20, and 30 mg/kg twice per day.
Properties of LY-3177833
| Boiling point: | 660.7±55.0 °C(Predicted) |
| Density | 1.398±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:30.0(Max Conc. mg/mL);96.99(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.67±0.40(Predicted) |
| color | White to off-white |
Safety information for LY-3177833
Computed Descriptors for LY-3177833
New Products
9-Mesityl-10-methylacridinium perchlorate Sulfapyridine Fmoc-OSu (R)-(-)-2-Amino-1-propanol Cyclobutanone 5-bromo-4-fluoro-2-nitrobenzaldehyde 4 pentyn 1 ol N-Vinylformamide Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamideRelated products of tetrahydrofuran
![Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2](https://img.chemicalbook.in/CAS/20211123/GIF/1088715-84-7.gif)
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