LY 334370 HYDROCHLORIDE
Synonym(s):4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate
- CAS NO.：182563-08-2
- Empirical Formula: C21H22FN3O
- Molecular Weight: 351.42
- MDL number: MFCD11519957
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-07-16 07:06:08
What is LY 334370 HYDROCHLORIDE?
The Uses of LY 334370 HYDROCHLORIDE
LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes.
What are the applications of Application
LY 334370 hydrochloride is a selective SR-1F agonist
Biological Activity
Selective 5-HT 1F receptor agonist (K i values are 1.87, 16.4, > 100 (IC 50 ), 176, 189, 281, 1280, 1530, 1550, > 3000 (IC 50 ) and 3250 nM for 5-HT 1F , 5-HT 1A , 5-HT 4 , 5-HT 1E , 5-HT 1B , 5-HT 1D , 5-HT 2B , 5-HT 2A , 5-HT 7 , 5-HT 6 and 5-HT 2C receptors respectively). Displays antimigraine effects.
Properties of LY 334370 HYDROCHLORIDE
| Boiling point: | 479.1±45.0 °C(Predicted) |
| Density | 1.267±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | H2O: ≥5mg/mL (warmed) |
| form | powder |
| pka | 13.98±0.43(Predicted) |
| color | white to tan |
Safety information for LY 334370 HYDROCHLORIDE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for LY 334370 HYDROCHLORIDE
New Products
Dibenzoyl-L-tartaric acid Anhydrous (Resolution Reagent) Cis-Tosylate Dibenzo[b,f][1,4]thiazepin-11(10H)-one 1,2,3,9-Tetrahydro-9-Methyl-4H-Carbazole-4-One 1-(4-methoxyphenyl)-4-(4-Nitrophenyl)Piperazine (IT-1) BOC Piperazine 1-Benzhydrylazetane-3-carbonitrile 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione (±)-amino(2-fluorophenyl)acetic acid 2-(2-Chlorophenyl)glycine AMINO-(3-CHLORO-PHENYL)-ACETIC ACID 2'-Fluoroacetophenone METHANOL-D1(OD) TERTIARY BUTANOL-D9 N-ETHYL-D5-AMINE HYDROCHLORIDE BENZOIC ACID-D CHLOROFORM-D TOLUENE-D3 Trans,trans muconic acid HC Blue-16 4-Amino-2-chloro-6,7-dimethoxyquinazoline Ethyl 4,5-bis(2-methoxyethoxy)-2-nitrobenzoate 2,3-Dimethoxypyridine 1-(3-Chlorophenyl)piperazine hydrochlorideRelated products of tetrahydrofuran
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